The potential of mid infrared spectroscopy (MIRS) for real time bioprocess monitoring

B. McNeil, L.M. Harvey, P. Roychoudhury

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The need for effective bioprocess (fermentation) monitoring is growing in importance due to the rapid pace of change in the fermentation industry, and attendant financial pressures. Vibrational spectroscopy has shown great promise in bioprocess monitoring. In particular, recently attention has been focused on the capability of mid infrared spectroscopy (MIRS) to monitor multiple analytes in highly complex fermentation fluids. The potential of this powerful analytical technique is critically evaluated by discussion of relevant studies. The advantages and limitations of MIR are discussed in the context of "rival" technologies, such as near infrared, focusing especially on employing such techniques in bioprocesses for real time (either in situ or ex situ) measurements. The potential barriers to the development of MIRS for real time monitoring are identified and further research directions highlighted.
Original languageEnglish
Pages (from-to)159-166
Number of pages7
JournalAnalytica Chimica Acta
Volume571
Issue number2
DOIs
Publication statusPublished - 2006

Fingerprint

infrared spectroscopy
Fermentation
fermentation
Infrared spectroscopy
Spectrum Analysis
Monitoring
monitoring
Vibrational spectroscopy
analytical method
near infrared
Industry
spectroscopy
Infrared radiation
Technology
Pressure
Fluids
fluid
industry
Research

Keywords

  • bioprocess monitoring
  • fermentation
  • mid infrared spectroscopy
  • pharmacology
  • chemistry

Cite this

McNeil, B. ; Harvey, L.M. ; Roychoudhury, P. / The potential of mid infrared spectroscopy (MIRS) for real time bioprocess monitoring. In: Analytica Chimica Acta. 2006 ; Vol. 571, No. 2. pp. 159-166.
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The potential of mid infrared spectroscopy (MIRS) for real time bioprocess monitoring. / McNeil, B.; Harvey, L.M.; Roychoudhury, P.

In: Analytica Chimica Acta, Vol. 571, No. 2, 2006, p. 159-166.

Research output: Contribution to journalArticle

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