The population risk factors attributable to oral corticosteroids

TY - JOUR

T1 - The population risk factors attributable to oral corticosteroids

AU - Boyter, A.C.

PY - 2005

Y1 - 2005

N2 - Previous studies have indicated a relationship between oral corticosteroid use and the risk of fracture, although without population-based comparators or exact dose information. The aim was to estimate the relative and population attributable risk (PAR) of admission for non-traumatic fracture among users of corticosteroids. The design was a retrospective cohort study of the population of Tayside, Scotland aged 18 or over and resident between 1 January 1993 and 31 January 1997 (n = 280 645). Subjects included were those who redeemed one or more prescriptions for oral corticosteroids compared with those not prescribed corticosteroids (oral or inhaled) in the population. The main outcome measure was the PAR and relative risk of hospital admissions for non-traumatic fracture. Approximately 7.5% of the population received prescriptions for oral corticosteroids. There was a significantly higher risk of fracture in the oral corticosteroid cohort when exposed to drugs compared with the general population (RR = 1.90, 95%CI 1.68, 2.16), after adjustment. Women were at higher risk than men, especially for vertebral fractures (RR = 5.19, 95%CI 2.95, 9.16). Previous fracture, Parkinsonian and anti-epileptic medication were significantly associated with higher risk, while HRT, NSAIDS and statins were associated with lower risk. An estimate of one in six vertebral and 1 in 13 non-vertebral fractures could be due to oral corticosteroid use in the population. The important public health impact of oral corticosteroids, especially in women needs to be addressed. Greater use of medication to ameliorate the adverse effects of these widely-used drugs is advocated.

AB - Previous studies have indicated a relationship between oral corticosteroid use and the risk of fracture, although without population-based comparators or exact dose information. The aim was to estimate the relative and population attributable risk (PAR) of admission for non-traumatic fracture among users of corticosteroids. The design was a retrospective cohort study of the population of Tayside, Scotland aged 18 or over and resident between 1 January 1993 and 31 January 1997 (n = 280 645). Subjects included were those who redeemed one or more prescriptions for oral corticosteroids compared with those not prescribed corticosteroids (oral or inhaled) in the population. The main outcome measure was the PAR and relative risk of hospital admissions for non-traumatic fracture. Approximately 7.5% of the population received prescriptions for oral corticosteroids. There was a significantly higher risk of fracture in the oral corticosteroid cohort when exposed to drugs compared with the general population (RR = 1.90, 95%CI 1.68, 2.16), after adjustment. Women were at higher risk than men, especially for vertebral fractures (RR = 5.19, 95%CI 2.95, 9.16). Previous fracture, Parkinsonian and anti-epileptic medication were significantly associated with higher risk, while HRT, NSAIDS and statins were associated with lower risk. An estimate of one in six vertebral and 1 in 13 non-vertebral fractures could be due to oral corticosteroid use in the population. The important public health impact of oral corticosteroids, especially in women needs to be addressed. Greater use of medication to ameliorate the adverse effects of these widely-used drugs is advocated.

KW - osteoporosis

KW - public health

KW - oral corticosteroids

KW - fractures

U2 - 10.1002/pds.1075

DO - 10.1002/pds.1075

M3 - Article

VL - 14

SP - 177

EP - 186

JO - Pharmacoepidemiology and Drug Safety

T2 - Pharmacoepidemiology and Drug Safety

JF - Pharmacoepidemiology and Drug Safety

SN - 1053-8569

IS - 3

ER -