The pharmacology of galanthamine and its analogues

Research output: Contribution to journalLiterature review

142 Citations (Scopus)

Abstract

Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. At submicromolar concentrations, it inhibits acetylcholinesterase activity, but it is much less potent against butyrylcholinesterase activity. Galanthamine has been used in anaesthetics to reverse neuromuscular paralysis by tubocurarine-like muscle relaxants, but it is a tertiary amine that gets into the brain to cause central effects. Galanthamine is being studied as a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. Positive effects have been demonstrated in several learning and memory tests in animals.
LanguageEnglish
Pages113-128
Number of pages16
JournalPharmacology and Therapeutics
Volume68
Issue number1
DOIs
Publication statusPublished - 1995

Fingerprint

Galantamine
Pharmacology
Galanthus
Butyrylcholinesterase
Tubocurarine
Acetylcholinesterase
Alkaloids
Paralysis
Cholinergic Agents
Amines
Anesthetics
Alzheimer Disease
Learning
Muscles
Brain
Therapeutics

Keywords

  • animals
  • central nervous system
  • cholinesterase inhibitors
  • galantamine
  • humans
  • nootropic agents
  • parasympathomimetics

Cite this

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The pharmacology of galanthamine and its analogues. / Harvey, A L.

In: Pharmacology and Therapeutics, Vol. 68, No. 1, 1995, p. 113-128.

Research output: Contribution to journalLiterature review

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T1 - The pharmacology of galanthamine and its analogues

AU - Harvey, A L

PY - 1995

Y1 - 1995

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AB - Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. At submicromolar concentrations, it inhibits acetylcholinesterase activity, but it is much less potent against butyrylcholinesterase activity. Galanthamine has been used in anaesthetics to reverse neuromuscular paralysis by tubocurarine-like muscle relaxants, but it is a tertiary amine that gets into the brain to cause central effects. Galanthamine is being studied as a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. Positive effects have been demonstrated in several learning and memory tests in animals.

KW - animals

KW - central nervous system

KW - cholinesterase inhibitors

KW - galantamine

KW - humans

KW - nootropic agents

KW - parasympathomimetics

U2 - 10.1016/0163-7258(95)02002-0

DO - 10.1016/0163-7258(95)02002-0

M3 - Literature review

VL - 68

SP - 113

EP - 128

JO - Pharmacology and Therapeutics

T2 - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

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