The pharmacology of galanthamine and its analogues

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Abstract

Galanthamine is an alkaloid found in the bulbs of snowdrops and several Amaryllidaceae plants. At submicromolar concentrations, it inhibits acetylcholinesterase activity, but it is much less potent against butyrylcholinesterase activity. Galanthamine has been used in anaesthetics to reverse neuromuscular paralysis by tubocurarine-like muscle relaxants, but it is a tertiary amine that gets into the brain to cause central effects. Galanthamine is being studied as a possible therapeutic agent in Alzheimer's disease because of its central cholinergic effects. Positive effects have been demonstrated in several learning and memory tests in animals.
Original languageEnglish
Pages (from-to)113-128
Number of pages16
JournalPharmacology and Therapeutics
Volume68
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • animals
  • central nervous system
  • cholinesterase inhibitors
  • galantamine
  • humans
  • nootropic agents
  • parasympathomimetics

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