The pharmacological effects of cadmium on skeletal neuromuscular-transmission

M.F.M. Braga, E.G. Rowan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

1. 1. Cadmium (100 μ M) blocks neuromuscular transmission by blocking prejunctional voltage dependent calcium channels in a competitive manner. 2. 2. Prolonged exposure to cadmium leads to a block of neuromuscular transmission that is not competitive. 3. 3. Cadmium can increase the spontaneous release of acetylcholine, this release is modified by the cation composition of the bathing solution. 4. 4. Cadmium may enter the nerve terminal via the voltage dependent calcium channels (the L-type calcium channel has been implicated) and exert some of its actions intracellularly. 5. 5. All of the extracellular effects of cadmium can be reversed by cysteine.
Original languageEnglish
Pages (from-to)1729-1739
Number of pages10
JournalGeneral pharmacology
Volume25
Issue number8
DOIs
Publication statusPublished - Dec 1994

Keywords

  • cadmium
  • neuromuscular transmission
  • calcium channels
  • cysteine

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