The pharmacological effects of cadmium on skeletal neuromuscular-transmission

M.F.M. Braga, E.G. Rowan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1. 1. Cadmium (100 μ M) blocks neuromuscular transmission by blocking prejunctional voltage dependent calcium channels in a competitive manner. 2. 2. Prolonged exposure to cadmium leads to a block of neuromuscular transmission that is not competitive. 3. 3. Cadmium can increase the spontaneous release of acetylcholine, this release is modified by the cation composition of the bathing solution. 4. 4. Cadmium may enter the nerve terminal via the voltage dependent calcium channels (the L-type calcium channel has been implicated) and exert some of its actions intracellularly. 5. 5. All of the extracellular effects of cadmium can be reversed by cysteine.
LanguageEnglish
Pages1729-1739
Number of pages10
JournalGeneral pharmacology
Volume25
Issue number8
DOIs
Publication statusPublished - Dec 1994

Fingerprint

Cadmium
Pharmacology
Neuromuscular Blockade
Calcium Channels
L-Type Calcium Channels
Acetylcholine
Cysteine
Cations

Keywords

  • cadmium
  • neuromuscular transmission
  • calcium channels
  • cysteine

Cite this

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The pharmacological effects of cadmium on skeletal neuromuscular-transmission. / Braga, M.F.M.; Rowan, E.G.

In: General pharmacology, Vol. 25, No. 8, 12.1994, p. 1729-1739.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The pharmacological effects of cadmium on skeletal neuromuscular-transmission

AU - Braga, M.F.M.

AU - Rowan, E.G.

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AB - 1. 1. Cadmium (100 μ M) blocks neuromuscular transmission by blocking prejunctional voltage dependent calcium channels in a competitive manner. 2. 2. Prolonged exposure to cadmium leads to a block of neuromuscular transmission that is not competitive. 3. 3. Cadmium can increase the spontaneous release of acetylcholine, this release is modified by the cation composition of the bathing solution. 4. 4. Cadmium may enter the nerve terminal via the voltage dependent calcium channels (the L-type calcium channel has been implicated) and exert some of its actions intracellularly. 5. 5. All of the extracellular effects of cadmium can be reversed by cysteine.

KW - cadmium

KW - neuromuscular transmission

KW - calcium channels

KW - cysteine

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