The pedunculopontine tegmental nucleus: a role in cognitive processes?

Thomas Sleekier, Wendy Inglis, Philip Winn, Arjun Sahgal

Research output: Contribution to journalReview article

139 Citations (Scopus)

Abstract

The cholinergic pedunculopontine tegmental nucleus, located in the brainstem and part of the reticular formation, has been traditionally linked to motor function, arousal and sleep. Its anatomical connections, however, raise the possibility that the pedunculopontine tegmental nucleus is also involved in other aspects of behaviour such as motivation, attention and mnemonic processes. This is of obvious importance, since the pedunculopontine tegmental nucleus undergoes degeneration in human neurodegenerative disorders also characterized by attentional and/ or mnemonic deficits. Moreover, recent behavioural animal work suggests that cognitive processes may be represented in the pedunculopontine tegmental nucleus. The difficulty that faces research in this area, however, is the possible influence of cognition by other processes, such as arousal state, motivation and motor function. Nevertheless, by reviewing the literature, the pedunculopontine tegmental nucleus seems to be involved in attentional and possibly also in learning processes. These processes could be mediated by influencing cortical fuction via the thalamus, basal forebrain and basal ganglia. The involvement of the pedunculopontine tegmental nucleus in mechanisms of memory, however, seems to be rather unlikely.

LanguageEnglish
Pages298-318
Number of pages21
JournalBrain Research Reviews
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Jan 1994

Fingerprint

Pedunculopontine Tegmental Nucleus
Arousal
Motivation
Reticular Formation
Memory Disorders
Basal Ganglia
Thalamus
Neurodegenerative Diseases
Cognition
Cholinergic Agents
Brain Stem
Sleep
Learning
Research

Keywords

  • Acetylcholine
  • Arousal
  • Attention
  • Brainstem
  • Cognition
  • Learning
  • Memory
  • Motivation
  • Motor Function
  • Pedunculopontine nucleus
  • Reticular formation
  • neuroscience

Cite this

Sleekier, Thomas ; Inglis, Wendy ; Winn, Philip ; Sahgal, Arjun. / The pedunculopontine tegmental nucleus : a role in cognitive processes?. In: Brain Research Reviews. 1994 ; Vol. 19, No. 3. pp. 298-318.
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The pedunculopontine tegmental nucleus : a role in cognitive processes? / Sleekier, Thomas; Inglis, Wendy; Winn, Philip; Sahgal, Arjun.

In: Brain Research Reviews, Vol. 19, No. 3, 01.01.1994, p. 298-318.

Research output: Contribution to journalReview article

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