Abstract
| Language | English |
|---|---|
| Article number | 1554 |
| Number of pages | 14 |
| Journal | Nature Communications |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 5 Apr 2019 |
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Keywords
- human immune system
- inflammatory conditions
- rheumatoid arthritis
- ES-62
- parasitic worm
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The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. / Doonan, James; Tarafdar, Anuradha; Pineda, Miguel A.; Lumb, Felicity E.; Crowe, Jenny; Khan, Aneesah M.; Hoskisson, Paul A.; Harnett, Margaret M.; Harnett, William.
In: Nature Communications, Vol. 10, 1554, 05.04.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis
AU - Doonan, James
AU - Tarafdar, Anuradha
AU - Pineda, Miguel A.
AU - Lumb, Felicity E.
AU - Crowe, Jenny
AU - Khan, Aneesah M.
AU - Hoskisson, Paul A.
AU - Harnett, Margaret M.
AU - Harnett, William
PY - 2019/4/5
Y1 - 2019/4/5
N2 - The human immune system has evolved in the context of our colonisation by bacteria, viruses, fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears to have resulted in reduced microbiome diversity and generation of chronically activated immune systems, presaging the recent rise of allergic, autoimmune and metabolic disorders. Certainly, gastrointestinal helminths can protect against gut and lung mucosa inflammatory conditions by modulating the microbiome and suppressing the chronic inflammation associated with dysbiosis. Here, we employ ES-62, an immunomodulator secreted by tissue-dwelling Acanthocheilonema viteae to show that helminth-modulation of the gut microbiome does not require live infection with gastrointestinal-based worms nor is protection restricted to mucosal diseases. Specifically, subcutaneous administration of this defined immunomodulator affords protection against joint disease in collagen-induced arthritis, a mouse model of rheumatoid arthritis, which is associated with normalisation of gut microbiota and prevention of loss of intestinal barrier integrity.
AB - The human immune system has evolved in the context of our colonisation by bacteria, viruses, fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears to have resulted in reduced microbiome diversity and generation of chronically activated immune systems, presaging the recent rise of allergic, autoimmune and metabolic disorders. Certainly, gastrointestinal helminths can protect against gut and lung mucosa inflammatory conditions by modulating the microbiome and suppressing the chronic inflammation associated with dysbiosis. Here, we employ ES-62, an immunomodulator secreted by tissue-dwelling Acanthocheilonema viteae to show that helminth-modulation of the gut microbiome does not require live infection with gastrointestinal-based worms nor is protection restricted to mucosal diseases. Specifically, subcutaneous administration of this defined immunomodulator affords protection against joint disease in collagen-induced arthritis, a mouse model of rheumatoid arthritis, which is associated with normalisation of gut microbiota and prevention of loss of intestinal barrier integrity.
KW - human immune system
KW - inflammatory conditions
KW - rheumatoid arthritis
KW - ES-62
KW - parasitic worm
UR - https://www.nature.com/ncomms/
U2 - 10.1038/s41467-019-09361-0
DO - 10.1038/s41467-019-09361-0
M3 - Article
VL - 10
JO - Nature Communications
T2 - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 1554
ER -