Projects per year
Abstract
The human immune system has evolved in the context of our colonisation by bacteria, viruses, fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears to have resulted in reduced microbiome diversity and generation of chronically activated immune systems, presaging the recent rise of allergic, autoimmune and metabolic disorders. Certainly, gastrointestinal helminths can protect against gut and lung mucosa inflammatory conditions by modulating the microbiome and suppressing the chronic inflammation associated with dysbiosis. Here, we employ ES-62, an immunomodulator secreted by tissue-dwelling Acanthocheilonema viteae to show that helminth-modulation of the gut microbiome does not require live infection with gastrointestinal-based worms nor is protection restricted to mucosal diseases. Specifically, subcutaneous administration of this defined immunomodulator affords protection against joint disease in collagen-induced arthritis, a mouse model of rheumatoid arthritis, which is associated with normalisation of gut microbiota and prevention of loss of intestinal barrier integrity.
Original language | English |
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Article number | 1554 |
Number of pages | 14 |
Journal | Nature Communications |
Volume | 10 |
DOIs | |
Publication status | Published - 5 Apr 2019 |
Keywords
- human immune system
- inflammatory conditions
- rheumatoid arthritis
- ES-62
- parasitic worm
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William Harnett
- Strathclyde Institute Of Pharmacy And Biomedical Sciences - Visiting Professor
Person: Visiting Professor
Projects
- 1 Finished
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MIMIC - Do parasitic worms and their secreted immunomudulators protect against musculosketal disease by impacting on the host microbiome?
Harnett, W. (Principal Investigator) & Hoskisson, P. (Co-investigator)
Versus Arthritis (formerly Arthritis Research UK ARUK)
1/10/15 → 30/06/18
Project: Research