The NPAS3 gene--emerging evidence for a role in psychiatric illness

Benjamin S. Pickard, Andrew A. Pieper, David J. Porteous, Douglas H. Blackwood, Walter J. Muir

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.
LanguageEnglish
Pages439-448
Number of pages10
JournalAnnals of medicine
Volume38
Issue number6
DOIs
Publication statusPublished - 2006

Fingerprint

Psychiatry
Helix-Loop-Helix Motifs
Genes
Neurogenesis
Knockout Mice
Transcription Factors
Brain
Population

Keywords

  • behaviour
  • bipolar disorder
  • hippocampus
  • neurogenesis
  • schizophrenia
  • transcription factor
  • translocation

Cite this

Pickard, B. S., Pieper, A. A., Porteous, D. J., Blackwood, D. H., & Muir, W. J. (2006). The NPAS3 gene--emerging evidence for a role in psychiatric illness. Annals of medicine, 38(6), 439-448. https://doi.org/10.1080/07853890600946500
Pickard, Benjamin S. ; Pieper, Andrew A. ; Porteous, David J. ; Blackwood, Douglas H. ; Muir, Walter J. / The NPAS3 gene--emerging evidence for a role in psychiatric illness. In: Annals of medicine. 2006 ; Vol. 38, No. 6. pp. 439-448.
@article{5016e17c0d864acdb7121808edb576af,
title = "The NPAS3 gene--emerging evidence for a role in psychiatric illness",
abstract = "NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.",
keywords = "behaviour, bipolar disorder, hippocampus, neurogenesis , schizophrenia, transcription factor, translocation",
author = "Pickard, {Benjamin S.} and Pieper, {Andrew A.} and Porteous, {David J.} and Blackwood, {Douglas H.} and Muir, {Walter J.}",
year = "2006",
doi = "10.1080/07853890600946500",
language = "English",
volume = "38",
pages = "439--448",
journal = "Annals of medicine",
issn = "0785-3890",
number = "6",

}

Pickard, BS, Pieper, AA, Porteous, DJ, Blackwood, DH & Muir, WJ 2006, 'The NPAS3 gene--emerging evidence for a role in psychiatric illness' Annals of medicine, vol. 38, no. 6, pp. 439-448. https://doi.org/10.1080/07853890600946500

The NPAS3 gene--emerging evidence for a role in psychiatric illness. / Pickard, Benjamin S.; Pieper, Andrew A.; Porteous, David J.; Blackwood, Douglas H.; Muir, Walter J.

In: Annals of medicine, Vol. 38, No. 6, 2006, p. 439-448.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The NPAS3 gene--emerging evidence for a role in psychiatric illness

AU - Pickard, Benjamin S.

AU - Pieper, Andrew A.

AU - Porteous, David J.

AU - Blackwood, Douglas H.

AU - Muir, Walter J.

PY - 2006

Y1 - 2006

N2 - NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

AB - NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

KW - behaviour

KW - bipolar disorder

KW - hippocampus

KW - neurogenesis

KW - schizophrenia

KW - transcription factor

KW - translocation

UR - http://www.ncbi.nlm.nih.gov/pubmed/17008307

U2 - 10.1080/07853890600946500

DO - 10.1080/07853890600946500

M3 - Article

VL - 38

SP - 439

EP - 448

JO - Annals of medicine

T2 - Annals of medicine

JF - Annals of medicine

SN - 0785-3890

IS - 6

ER -