The NPAS3 gene--emerging evidence for a role in psychiatric illness

Benjamin S. Pickard; Andrew A. Pieper; David J. Porteous; Douglas H. Blackwood; Walter J. Muir

doi:10.1080/07853890600946500

The NPAS3 gene--emerging evidence for a role in psychiatric illness

Benjamin S. Pickard, Andrew A. Pieper, David J. Porteous, Douglas H. Blackwood, Walter J. Muir

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

Original language	English
Pages (from-to)	439-448
Number of pages	10
Journal	Annals of medicine
Volume	38
Issue number	6
DOIs	https://doi.org/10.1080/07853890600946500
Publication status	Published - 2006

Keywords

behaviour
bipolar disorder
hippocampus
neurogenesis
schizophrenia
transcription factor
translocation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/07853890600946500

Cite this

@article{5016e17c0d864acdb7121808edb576af,

title = "The NPAS3 gene--emerging evidence for a role in psychiatric illness",

abstract = "NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.",

keywords = "behaviour, bipolar disorder, hippocampus, neurogenesis , schizophrenia, transcription factor, translocation",

author = "Pickard, {Benjamin S.} and Pieper, {Andrew A.} and Porteous, {David J.} and Blackwood, {Douglas H.} and Muir, {Walter J.}",

year = "2006",

doi = "10.1080/07853890600946500",

language = "English",

volume = "38",

pages = "439--448",

journal = "Annals of medicine",

issn = "0785-3890",

number = "6",

}

TY - JOUR

T1 - The NPAS3 gene--emerging evidence for a role in psychiatric illness

AU - Pickard, Benjamin S.

AU - Pieper, Andrew A.

AU - Porteous, David J.

AU - Blackwood, Douglas H.

AU - Muir, Walter J.

PY - 2006

Y1 - 2006

N2 - NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

AB - NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

KW - behaviour

KW - bipolar disorder

KW - hippocampus

KW - neurogenesis

KW - schizophrenia

KW - transcription factor

KW - translocation

UR - http://www.ncbi.nlm.nih.gov/pubmed/17008307

U2 - 10.1080/07853890600946500

DO - 10.1080/07853890600946500

M3 - Article

SN - 0785-3890

VL - 38

SP - 439

EP - 448

JO - Annals of medicine

JF - Annals of medicine

IS - 6

ER -

The NPAS3 gene--emerging evidence for a role in psychiatric illness

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this