The neuroanatomical substrate of lexical-semantic decline in MCI APOE epsilon 4 carriers and noncarriers

Annalena Venneri, William J. McGeown, Roberta Biundo, Marco Mion, Paolo Nichelli, Michael F. Shanks

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lexical-semantic competency in mild cognitive impairment (MCI) epsilon 4 carriers was used as an endophenotype, and gray matter volume in MCI epsilon 4 carriers/noncarriers and in noncarrier controls was compared. Residual gray matter volumes were correlated with age of acquisition values for words from a category fluency task, an index of semantic competency. MCI patients had significantly impoverished lexical-semantic output compared with controls, more marked in MCI epsilon 4 carriers. Smaller volumes in the left hippocampus, bilateral regions of the uncus, and posterior cingulate cortex were associated with a tendency to retrieve earlier acquired words in the category fluency task in MCI epsilon 4 carriers, whereas poor semantic performance in MCI noncarriers was associated with smaller volumes in the left uncus, bilateral regions of the parahippocampal gyrus, and hippocampus, and also in a large number of neocortical regions. There was a significant semantic competency by genotype interaction in the left perirhinal cortex, in a number of left frontal and temporal areas and in the right inferior parietal lobule and precuneus. MCI epsilon 4 carriers, when compared with noncarriers, had lower gray matter volume values confined to the right precuneus and the cerebellum bilaterally, but the converse comparison showed that MCI noncarriers had lower values in extensive frontal, temporal, and parietal regions of the neocortex. Similar brain volumetric variations linked to genotype were found in minimal-to-mild AD. The results suggest a relatively specific impact of apolipoprotein E (APOE) epsilon 4 burden and underline the value of linguistic assessment in preclinical diagnosis.

LanguageEnglish
Pages230-241
Number of pages12
JournalAlzheimer Disease and Associated Disorders
Volume25
Issue number3
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Apolipoprotein E4
Semantics
Parietal Lobe
Parahippocampal Gyrus
Genotype
Endophenotypes
Cognitive Dysfunction
Neocortex
Gyrus Cinguli
Temporal Lobe
Linguistics
Cerebellum
Hippocampus
Brain

Keywords

  • mild cognitive impairment
  • frontotemporal dementia
  • age of acquisition
  • magnetic resonance imaging
  • genetic risk
  • brain activation
  • verbal fluency task
  • international workshop
  • hippocampal atrophy
  • APOE
  • neuropsychiatric symptoms
  • Alzheimer disease
  • apolipoprotein-E genotype
  • endophenotype
  • lexical
  • early Alzheimers disease

Cite this

Venneri, Annalena ; McGeown, William J. ; Biundo, Roberta ; Mion, Marco ; Nichelli, Paolo ; Shanks, Michael F. / The neuroanatomical substrate of lexical-semantic decline in MCI APOE epsilon 4 carriers and noncarriers. In: Alzheimer Disease and Associated Disorders. 2011 ; Vol. 25, No. 3. pp. 230-241.
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The neuroanatomical substrate of lexical-semantic decline in MCI APOE epsilon 4 carriers and noncarriers. / Venneri, Annalena; McGeown, William J.; Biundo, Roberta; Mion, Marco; Nichelli, Paolo; Shanks, Michael F.

In: Alzheimer Disease and Associated Disorders, Vol. 25, No. 3, 07.2011, p. 230-241.

Research output: Contribution to journalArticle

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T1 - The neuroanatomical substrate of lexical-semantic decline in MCI APOE epsilon 4 carriers and noncarriers

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AU - McGeown, William J.

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KW - neuropsychiatric symptoms

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