The Natural Products Atlas 3.0: extending the database of microbially derived natural products

Ella F Poynton, Jeffrey A van Santen, Matthew Pin, Marla Macias Contreras, Emily McMann, Jonathan Parra, Brandon Showalter, Liana Zaroubi, Katherine R Duncan, Roger G Linington*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthetic and chemical ontology classifications, grouping by compound classes and cross-links to a suite of other natural product-related data resources. The database is supported by a web server that includes functionality to browse the collection, search the database using both chemical structures and text/numerical terms and visualize the chemical diversity it contains using interactive dashboards. In the current database release, we have curated 1347 papers, increasing the number of compounds to 36 545. In addition, we have initiated a large-scale effort to incorporate data from papers reporting structural reassignments and revisions to previously published structures. This effort led to the incorporation of 590 corrections to existing entries, significantly improving the accuracy of the dataset. The Natural Products Atlas may be accessed at www.npatlas.org.
Original languageEnglish
Article numbergkae1093
Pages (from-to)D691-D699
JournalNucleic Acids Research
Volume53
Issue numberD1
Early online date26 Nov 2024
DOIs
Publication statusE-pub ahead of print - 26 Nov 2024

Keywords

  • microbially derived natural products
  • Natural Products Atlas
  • database

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