The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

Z.A. Saddiq; J.C. Barbenel; M.H. Grant

The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

Z.A. Saddiq, J.C. Barbenel, M.H. Grant

Electronic And Electrical Engineering

Research output: Contribution to conference › Paper

2 Citations (Scopus)

Abstract

Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).

Original language	English
Publication status	Published - 2005
Event	Tissue and Cell Engineering Society Meeting - London, England Duration: 20 May 2005 → 22 May 2005

Conference

Conference	Tissue and Cell Engineering Society Meeting
City	London, England
Period	20/05/05 → 22/05/05

Keywords

mechanical engineering
collagen gels
glycosaminoglycans
fibroblasts
crosslinked collagen
fibroblast populated collagen gels
collagen/glycosaminoglycan gels

Cite this

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title = "The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts",

abstract = "Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).",

keywords = "mechanical engineering, collagen gels, glycosaminoglycans, fibroblasts, crosslinked collagen, fibroblast populated collagen gels, collagen/glycosaminoglycan gels",

author = "Z.A. Saddiq and J.C. Barbenel and M.H. Grant",

note = "Also published in: 1. Journal of Biomedical Materials Research Part A (2008), 89A(3), pp697-706. 2. European Cells and Materials (2005), 10(S2), p64. (This is a variant record); Tissue and Cell Engineering Society Meeting ; Conference date: 20-05-2005 Through 22-05-2005",

year = "2005",

language = "English",

}

TY - CONF

T1 - The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

AU - Saddiq, Z.A.

AU - Barbenel, J.C.

AU - Grant, M.H.

N1 - Also published in: 1. Journal of Biomedical Materials Research Part A (2008), 89A(3), pp697-706. 2. European Cells and Materials (2005), 10(S2), p64. (This is a variant record)

PY - 2005

Y1 - 2005

N2 - Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).

AB - Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).

KW - mechanical engineering

KW - collagen gels

KW - glycosaminoglycans

KW - fibroblasts

KW - crosslinked collagen

KW - fibroblast populated collagen gels

KW - collagen/glycosaminoglycan gels

UR - http://www.tces.org/

UR - http://www.ecmjournal.org/journal/supplements/vol010supp02/pdf/vol010supp02a64.pdf

UR - http:///dx.doi.org/10.1002/jbm.a.32007

UR - http://strathprints.strath.ac.uk/18399/

M3 - Paper

T2 - Tissue and Cell Engineering Society Meeting

Y2 - 20 May 2005 through 22 May 2005

ER -

The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

Abstract

Conference

Keywords

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The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

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