The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

Z.A. Saddiq, J.C. Barbenel, M.H. Grant

Research output: Contribution to conferencePaper

2 Citations (Scopus)

Abstract

Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).

Conference

ConferenceTissue and Cell Engineering Society Meeting
CityLondon, England
Period20/05/0522/05/05

Fingerprint

Glycosaminoglycans
Collagen
Fibroblasts
Gels
Putrescine
Polyamines
Tissue Engineering

Keywords

  • mechanical engineering
  • collagen gels
  • glycosaminoglycans
  • fibroblasts
  • crosslinked collagen
  • fibroblast populated collagen gels
  • collagen/glycosaminoglycan gels

Cite this

Saddiq, Z. A., Barbenel, J. C., & Grant, M. H. (2005). The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts. Paper presented at Tissue and Cell Engineering Society Meeting, London, England, .
Saddiq, Z.A. ; Barbenel, J.C. ; Grant, M.H. / The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts. Paper presented at Tissue and Cell Engineering Society Meeting, London, England, .
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abstract = "Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).",
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note = "Also published in: 1. Journal of Biomedical Materials Research Part A (2008), 89A(3), pp697-706. 2. European Cells and Materials (2005), 10(S2), p64. (This is a variant record); Tissue and Cell Engineering Society Meeting ; Conference date: 20-05-2005 Through 22-05-2005",
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Saddiq, ZA, Barbenel, JC & Grant, MH 2005, 'The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts' Paper presented at Tissue and Cell Engineering Society Meeting, London, England, 20/05/05 - 22/05/05, .

The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts. / Saddiq, Z.A.; Barbenel, J.C.; Grant, M.H.

2005. Paper presented at Tissue and Cell Engineering Society Meeting, London, England, .

Research output: Contribution to conferencePaper

TY - CONF

T1 - The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts

AU - Saddiq, Z.A.

AU - Barbenel, J.C.

AU - Grant, M.H.

N1 - Also published in: 1. Journal of Biomedical Materials Research Part A (2008), 89A(3), pp697-706. 2. European Cells and Materials (2005), 10(S2), p64. (This is a variant record)

PY - 2005

Y1 - 2005

N2 - Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).

AB - Collagen based scaffolds are widely used for tissue engineering strategies; many are designed to biodegrade gradually and become populated with host cells. The effect of infiltration by host cells on the mechanical properties of the scaffolds is unclear. We have used fibroblast populated collagen lattices to study the effects of the presence of 3T3 mouse fibroblasts on the mechanical properties of collagen gels containing glycosaminoglycans (GAGs) crosslinked with the carbodiimide, 1,1-carbonyldiimidazole (CDI), and the polyamine, putrescine (Put).

KW - mechanical engineering

KW - collagen gels

KW - glycosaminoglycans

KW - fibroblasts

KW - crosslinked collagen

KW - fibroblast populated collagen gels

KW - collagen/glycosaminoglycan gels

UR - http://www.tces.org/

UR - http://www.ecmjournal.org/journal/supplements/vol010supp02/pdf/vol010supp02a64.pdf

UR - http:///dx.doi.org/10.1002/jbm.a.32007

UR - http://strathprints.strath.ac.uk/18399/

M3 - Paper

ER -

Saddiq ZA, Barbenel JC, Grant MH. The mechanical strength of collagen gels containing glycosaminoglycans and populated with fibroblasts. 2005. Paper presented at Tissue and Cell Engineering Society Meeting, London, England, .