Abstract
The isolation, identification and total synthesis of two plant-derived inhibitors of the NF-κB signaling pathway from the iso-seco-tanapartholide family of natural products is described. A key step in the efficient reaction sequence is a late-stage oxidative cleavage reaction that was carried out in the absence of protecting groups to give the natural products directly. A detailed comparison of the synthetic material with samples of the natural products proved informative. Biological studies on synthetic material confirmed that these compounds act late in the NF-κB signaling pathway.
Original language | English |
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Pages (from-to) | 5711-5715 |
Number of pages | 4 |
Journal | Agewandte Chemie-International Edition |
Volume | 2009 |
Issue number | 33 |
DOIs | |
Publication status | Published - 7 Oct 2009 |
Keywords
- natural products
- total synthesis
- terpenoids
- cleavage reaction
- inflammation