The interplay between human b cells, eosinophils and helminths: a novel aspect of the hygiene hypothesis

A. Mammen, F.A. Farraye, Y. Liang, W. Harnett, H. Shin, M.M. Harnett, B. Nikolajczyk, L. Ganley-Leal

Research output: Contribution to journalArticle


The hygiene hypothesis is based on the premise that lack of exposure to helminths predisposes certain individuals to immune-mediated disease, such as inflammatory bowel disease (IBD). This hypothesis is supported by epidemiological data that shows developed countries with a low prevalence of helminth infections have higher incidence of allergic and inflammatory diseases. Helminths modulate the host immune response in a manner that dampens the exaggerated response to innocuous antigens, such as commensal bacteria.
Original languageEnglish
Pages (from-to)337-338
Number of pages1
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number6
Publication statusPublished - Dec 2008


  • human b cells
  • eosinophils
  • helminth
  • hygiene hypothesis
  • immune-mediated disease
  • inflammatory bowel disease

Cite this