The hygiene hypothesis is based on the premise that lack of exposure to helminths predisposes certain individuals to immune-mediated disease, such as inflammatory bowel disease (IBD). This hypothesis is supported by epidemiological data that shows developed countries with a low prevalence of helminth infections have higher incidence of allergic and inflammatory diseases. Helminths modulate the host immune response in a manner that dampens the exaggerated response to innocuous antigens, such as commensal bacteria.
|Number of pages||1|
|Journal||American Journal of Tropical Medicine and Hygiene|
|Publication status||Published - Dec 2008|
- human b cells
- hygiene hypothesis
- immune-mediated disease
- inflammatory bowel disease
Mammen, A., Farraye, F. A., Liang, Y., Harnett, W., Shin, H., Harnett, M. M., ... Ganley-Leal, L. (2008). The interplay between human b cells, eosinophils and helminths: a novel aspect of the hygiene hypothesis. American Journal of Tropical Medicine and Hygiene, 79(6), 337-338.