The interaction of hexavalent chromium with mouse macrophages

A. Lalaouni; C. Kupper; M.H. Grant

doi:10.1016/S0300-483X(03)00254-3

The interaction of hexavalent chromium with mouse macrophages

A. Lalaouni, C. Kupper, M.H. Grant

Research output: Contribution to journal › Article › peer-review

Abstract

Many orthopaedic implants are made of stainless steel or cobalt–chrome alloys which degrade in vivo, releasing metal ions and particles into the body. This can lead to loosening of prostheses through local inflammatory processes and toxicity to adjacent tissues. Cr VI is one of the most toxic ions released from metal implants, and concentrations up to 2 mM have been measured in tissues samples adjacent to retrieved implants (Blumenthal et al., 1994). It is well recognised as a carcinogen in man (Langard, 1983) although the mechanism of action is undetermined. In this study Cr VI toxicity to macrophages was assessed in vitro using the J774.1 murine macrophage cell line.

Original language	English
Pages (from-to)	86-86
Number of pages	1
Journal	Toxicology
Volume	192
Issue number	1
DOIs	https://doi.org/10.1016/S0300-483X(03)00254-3
Publication status	Published - 2002

Keywords

mouse macrophages
hexavalent chromium
toxicology

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title = "The interaction of hexavalent chromium with mouse macrophages",

abstract = "Many orthopaedic implants are made of stainless steel or cobalt–chrome alloys which degrade in vivo, releasing metal ions and particles into the body. This can lead to loosening of prostheses through local inflammatory processes and toxicity to adjacent tissues. Cr VI is one of the most toxic ions released from metal implants, and concentrations up to 2 mM have been measured in tissues samples adjacent to retrieved implants (Blumenthal et al., 1994). It is well recognised as a carcinogen in man (Langard, 1983) although the mechanism of action is undetermined. In this study Cr VI toxicity to macrophages was assessed in vitro using the J774.1 murine macrophage cell line.",

keywords = "mouse macrophages , hexavalent chromium , toxicology",

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note = "Selected Papers and Abstracts of the British Toxicology Society Annual Congress, (UMIST)",

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AU - Grant, M.H.

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AB - Many orthopaedic implants are made of stainless steel or cobalt–chrome alloys which degrade in vivo, releasing metal ions and particles into the body. This can lead to loosening of prostheses through local inflammatory processes and toxicity to adjacent tissues. Cr VI is one of the most toxic ions released from metal implants, and concentrations up to 2 mM have been measured in tissues samples adjacent to retrieved implants (Blumenthal et al., 1994). It is well recognised as a carcinogen in man (Langard, 1983) although the mechanism of action is undetermined. In this study Cr VI toxicity to macrophages was assessed in vitro using the J774.1 murine macrophage cell line.

KW - mouse macrophages

KW - hexavalent chromium

KW - toxicology

U2 - 10.1016/S0300-483X(03)00254-3

DO - 10.1016/S0300-483X(03)00254-3

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EP - 86

JO - Toxicology

JF - Toxicology

SN - 0300-483X

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