The interaction of bisphosphonate-coated hydroxyapatite and osteoblasts

A. Ganguli, A.W. Lloyd, S.T. Meikle, M.H. Grant

    Research output: Chapter in Book/Report/Conference proceedingChapter


    Coating of the hydroxyapatite (HA) ceramic component of artificial hip joints with the bisphosphonates clodronate (C) and pamidronate (P) has been proposed as a means to minimise osteolysis and thereby prevent loosening of the implant. However, the effect of the bisphosphonate coating on bacterial adhesion to the HA materials must be determined before this approach can be implemented.
    Original languageEnglish
    Title of host publicationTransactions of the 25th Annual Meeting of the Society for Biomaterials
    Publication statusPublished - 2001


    • bisphosphonate-coated hydroxyapatite
    • osteoblasts
    • biotechnology


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