The inner gel component of aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells

V.A. Ferro, F. Habeeb, Graham Stables, F. Bradbury, S. nong, P. Cameron, R.J. Plevin

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of Aloe barbadensis Miller. A simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely TNF-α and IL-1β, from peripheral blood leukocytes stimulated with Shigella flexneri or LPS. This report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health drink from the same source. Comparison was made with a human monocytic cell-line (THP-1 cells) and a similar trend in responses was demonstrated.
Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalMethods
Volume42
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Gels
Cytokines
Aloe
Shigella flexneri
Interleukin-1
Powders
Assays
Leukocytes
Blood
Anti-Inflammatory Agents
Health
Cell Line
Aloe vera gel
In Vitro Techniques

Keywords

  • aloe vera
  • anti-inflammatory
  • inflammation
  • pro-inflammatory cytokines

Cite this

Ferro, V.A. ; Habeeb, F. ; Stables, Graham ; Bradbury, F. ; nong, S. ; Cameron, P. ; Plevin, R.J. / The inner gel component of aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. In: Methods. 2007 ; Vol. 42, No. 4. pp. 388-393.
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The inner gel component of aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. / Ferro, V.A.; Habeeb, F.; Stables, Graham; Bradbury, F.; nong, S.; Cameron, P.; Plevin, R.J.

In: Methods, Vol. 42, No. 4, 2007, p. 388-393.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The inner gel component of aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells

AU - Ferro, V.A.

AU - Habeeb, F.

AU - Stables, Graham

AU - Bradbury, F.

AU - nong, S.

AU - Cameron, P.

AU - Plevin, R.J.

PY - 2007

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N2 - The present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of Aloe barbadensis Miller. A simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely TNF-α and IL-1β, from peripheral blood leukocytes stimulated with Shigella flexneri or LPS. This report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health drink from the same source. Comparison was made with a human monocytic cell-line (THP-1 cells) and a similar trend in responses was demonstrated.

AB - The present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of Aloe barbadensis Miller. A simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely TNF-α and IL-1β, from peripheral blood leukocytes stimulated with Shigella flexneri or LPS. This report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health drink from the same source. Comparison was made with a human monocytic cell-line (THP-1 cells) and a similar trend in responses was demonstrated.

KW - aloe vera

KW - anti-inflammatory

KW - inflammation

KW - pro-inflammatory cytokines

U2 - 10.1016/j.ymeth.2007.03.005

DO - 10.1016/j.ymeth.2007.03.005

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