The influence of prosthesis size and design on exercise dynamics after aortic valve replacement

Niaz F. Ali, Vinod S. Mahadevan, Andrew Muir, Christine Maguire, David Young, Gianfranco Campalani, Norman P S Campbell, Mark H D Danton

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background and aim of the study: Residual gradient following aortic valve replacement (AVR) may adversely affect clinical outcome. The size and design of the valve may influence these characteristics. The study aim was to determine the influence of prosthesis physical size and leaflet design on hemodynamic performance after mechanical AVR. Methods: After AVR, two patient groups with a range of valve sizes were studied. Group 1 patients (n = 19) each received a monoleaflet valve; group 2 patients (n = 18) each received a bileaflet valve. Transthoracic echocardiography was performed at rest and after graded bicycle ergometry to assess prosthetic valve parameters, including mean and peak transvalvular gradient and effective orifice area (EOA). Results: Transprosthetic gradients (mean and peak) measured at rest, maximum exercise and 3- min recovery were related to indexed geometric orifice area (IGOA) by an exponential decay function, with no significant advantage for either valve design. However, in valve sizes ≤25 mm the bileaflet valves demonstrated lower gradients, both at rest and under exercise conditions (mean gradient during exercise, bileaflet versus monoleaflet 19.9 ± 7.2 mmHg versus 25.6 ± 6.3 mmHg, p = 0.01). Similarly, EOAs were larger in the bileaflet group when equivalent GOAs ≤2.5 cm2 were compared (EOA: bileaflet versus monoleaflet 1.51 ± 0.33 cm2 versus 1.14 ± 0.26 cm2, p = 0.018). The total work performed correlated with prosthesis diameter (r2 = 0.81, p = 0.037) and was not influenced by valve design. Conclusion: The hemodynamic performance of mechanical aortic valves, including transprosthetic gradient and maximum exercise work performed, related principally to the prosthesis physical size. However, within the smaller valve sizes, the bileaflet design appeared to offer hemodynamic advantages.

Original languageEnglish
Pages (from-to)755-762
Number of pages8
JournalJournal of Heart Valve Disease
Issue number6
Publication statusPublished - 1 Nov 2006


  • prosthesis size
  • prosthesis design
  • aortic valve replacement


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