The influence of hepatitis C and alcohol on liver-related morbidity and mortality in Glasgow

S. McDonald, S. Hutchinson, P. Mills, S. Bird, S. Cameron, J. Dillon, D. Goldberg

Research output: Contribution to journalConference Contribution

13 Citations (Scopus)

Abstract

Presented as part of poster session 2: chronic disease. This presesentation looks at infection with the hepatitis C virus (HCV) is associated with the development of severe liver disease, but cofactors – namely alcohol abuse – in Scotlands HCV-positive population complicate estimation of the unique contribution of HCV. We compared the risk of hospital admission/death for a liver-related cause in a large cohort of Glasgow's injecting drug users (IDUs) testing HCV-positive, with IDUs testing HCV-negative.

Data for 6566 current/former IDUs who had been tested for anti-HCV and/or HCV RNA in Greater Glasgow health board between 1993 and 2007 were linked to the national hospitalisation database and deaths registry to identify all admissions and deaths from a liver-related condition. RRs were estimated using Cox regression for recurrent events.

The risk of hospitalisation/death from a liver-related or an alcoholic liver-related condition following HCV testing was greater for those IDUs with no prior alcohol-related hospitalisation who tested positive [adjusted hazard ratio (HR) = 3.2, 95% CI 1.5 to 6.7; 4.9, 95% CI 1.8 to 13.1, respectively], compared with those who tested anti-HCV negative, but not for those IDUs with a prior alcohol admission (HR=0.8, 95% CI 0.4 to 1.5; 0.8, 95% CI 0.4 to 1.6). There was little evidence for an increased risk of hospitalisation/death for an exclusively non-alcoholic liver condition for those testing positive (HR=1.5, 95% CI 0.8 to 2.7), after adjustment for previous alcohol-related admission.

Within Glasgow's IDU population, HCV positivity is associated with an increased risk of a liver-related outcome, but this is not observed for those IDUs whose problem alcohol use already increases their risk.

Original languageEnglish
Pages (from-to)A271-A271
JournalJournal of Epidemiology and Community Health
Volume65
Issue numberSupplement 1
DOIs
Publication statusPublished - Aug 2011
EventIEA World Congress of Epidemiology - Edinburgh, United Kingdom
Duration: 7 Aug 201111 Aug 2011

Keywords

  • hepatitis C
  • alcohol
  • liver-related morbidity
  • mortality
  • glasgow
  • HCV
  • infection
  • influence

Cite this

McDonald, S., Hutchinson, S., Mills, P., Bird, S., Cameron, S., Dillon, J., & Goldberg, D. (2011). The influence of hepatitis C and alcohol on liver-related morbidity and mortality in Glasgow. Journal of Epidemiology and Community Health, 65(Supplement 1), A271-A271. https://doi.org/10.1136/jech.2011.142976j.17