The influence of cytokines on the glycosylation pattern of alpha-l-acid glycoprotein secreted by the HepC2 cell line

H G ELLIOTT, M A ELLIOTT, J WATSON, K D SMITH

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Alpha-I-acid glycoprotein (ACP) is a positive acute phase protein which exists as an heterogeneous populationn of glycosylated variants (glycoforms). A clearly defined function for ACP remains largely unknown however several studies have
demonstrated immunomodulatory properties. The ACP glycoforms associated
with chronic inflammation have an increased number o f tri- or tetra- antennary structures to the detriment o f bi-antennary chains, and are more effective at immunomodulation.
Original languageEnglish
Pages (from-to)S164-S164
Number of pages1
JournalBiochemical Society Transactions
Volume23
Issue number2
DOIs
Publication statusPublished - May 1995

Keywords

  • proteins
  • cytokines
  • glycosylation
  • immunomodulation

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