The in vitro adsorption of cytokines by polymer-pyrolysed carbon

C.A. Howell; S.R. Sandeman; G.J. Phillips; A.W. Lloyd; J.A. Davies; S.V. Mikhalovsky; S.R. Tennison; A.P. Rawlinson; O.P. Kozynchenko; H.L.H. Owen; J.D.S. Gaylor; J.J. Rouse; J.M. Courtney

doi:10.1016/j.biomaterials.2006.05.041

The in vitro adsorption of cytokines by polymer-pyrolysed carbon

C.A. Howell, S.R. Sandeman, G.J. Phillips, A.W. Lloyd, J.A. Davies, S.V. Mikhalovsky, S.R. Tennison, A.P. Rawlinson, O.P. Kozynchenko, H.L.H. Owen, J.D.S. Gaylor, J.J. Rouse, J.M. Courtney

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

This study investigated a range of phenolformaldehydeaniline based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba® 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.

Original language	English
Pages (from-to)	5286-5291
Number of pages	5
Journal	Biomaterials
Volume	27
Issue number	30
DOIs	https://doi.org/10.1016/j.biomaterials.2006.05.041
Publication status	Published - 2006

Keywords

adsorption
carbon
cytokine
extracorporeal circulation
sepsis
bioengineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2006.05.041

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Howell, C. A., Sandeman, S. R., Phillips, G. J., Lloyd, A. W., Davies, J. A., Mikhalovsky, S. V., Tennison, S. R., Rawlinson, A. P., Kozynchenko, O. P., Owen, H. L. H., Gaylor, J. D. S., Rouse, J. J., & Courtney, J. M. (2006). The in vitro adsorption of cytokines by polymer-pyrolysed carbon. Biomaterials, 27(30), 5286-5291. https://doi.org/10.1016/j.biomaterials.2006.05.041

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title = "The in vitro adsorption of cytokines by polymer-pyrolysed carbon",

abstract = "This study investigated a range of phenolformaldehydeaniline based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba{\textregistered} 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.",

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AU - Howell, C.A.

AU - Sandeman, S.R.

AU - Phillips, G.J.

AU - Lloyd, A.W.

AU - Davies, J.A.

AU - Mikhalovsky, S.V.

AU - Tennison, S.R.

AU - Rawlinson, A.P.

AU - Kozynchenko, O.P.

AU - Owen, H.L.H.

AU - Gaylor, J.D.S.

AU - Rouse, J.J.

AU - Courtney, J.M.

PY - 2006

Y1 - 2006

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AB - This study investigated a range of phenolformaldehydeaniline based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba® 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.

KW - adsorption

KW - carbon

KW - cytokine

KW - extracorporeal circulation

KW - sepsis

KW - bioengineering

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U2 - 10.1016/j.biomaterials.2006.05.041

DO - 10.1016/j.biomaterials.2006.05.041

M3 - Article

SN - 0142-9612

VL - 27

SP - 5286

EP - 5291

JO - Biomaterials

JF - Biomaterials

IS - 30

ER -

The in vitro adsorption of cytokines by polymer-pyrolysed carbon

Abstract

Keywords

UN SDGs

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