The in vitro adsorption of cytokines by polymer-pyrolysed carbon

C.A. Howell, S.R. Sandeman, G.J. Phillips, A.W. Lloyd, J.A. Davies, S.V. Mikhalovsky, S.R. Tennison, A.P. Rawlinson, O.P. Kozynchenko, H.L.H. Owen, J.D.S. Gaylor, J.J. Rouse, J.M. Courtney

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32 Citations (Scopus)

Abstract

This study investigated a range of phenolformaldehydeaniline based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba® 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.
Original languageEnglish
Pages (from-to)5286-5291
Number of pages5
JournalBiomaterials
Volume27
Issue number30
DOIs
Publication statusPublished - 2006

Keywords

  • adsorption
  • carbon
  • cytokine
  • extracorporeal circulation
  • sepsis
  • bioengineering

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