The impact of solvent systems, process conditions and structurally related impurities on the growth rate and morphologies of paracetamol crystals

Chris John Price, Layla Mir Bruce, Thai Thu Hien Nguyen, Hailani Hadil

Research output: Contribution to conferencePaper

Abstract

Single crystal growth (S.C.G) experiments were conducted to investigate face specific growth rates of paracetamol (acetaminophen) crystals. There are a few examples in literature where S.C.G of paracetamol crystals and different process conditions are analysed [1] but no examples of the addition of structurally related impurities (Metacetamol and Acetanilide) can be found. Carefully selected conditions of supersaturation and temperature were also analysed. The resulting growth rates were then determined in two solvents, ethanol and 3-Methyl-1-butanol. The impact of the structurally related impurities on the solubility of paracetamol was determined in each of solvents investigated. The relative growth rates of pairs of faces and the associated habit change of monoclinic paracetamol was observed using in-situ optical microscopy. The respective growth rates increased with an increase of supersaturation and temperature, as the impurity concentration increased the relative growth rate of the faces decreased
Original languageEnglish
Publication statusPublished - 27 Jun 2016
EventCrystal Growth of Organic Materials - University of Leeds, Leeds, United Kingdom
Duration: 26 Jun 201630 Jun 2016
Conference number: 12
http://www.crystalgrowth2016.co.uk/wp-content/uploads/2016/06/CGOM-Conference-Programme.pdf

Conference

ConferenceCrystal Growth of Organic Materials
Abbreviated titleCGOM
CountryUnited Kingdom
CityLeeds
Period26/06/1630/06/16
Internet address

Keywords

  • crystal growth from solution
  • impurity
  • habit
  • kinetics

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    • 1 Invited talk

    Impurities: A neglected challenge

    Chris John Price (Contributor)

    1 Dec 2016

    Activity: Talk or presentation typesInvited talk

    Cite this

    Price, C. J., Mir Bruce, L., Nguyen, T. T. H., & Hadil , H. (2016). The impact of solvent systems, process conditions and structurally related impurities on the growth rate and morphologies of paracetamol crystals. Paper presented at Crystal Growth of Organic Materials, Leeds, United Kingdom.