The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle

D Tolan, A M Conway, L Steele, S Pyne, N J Pyne

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We present entirely novel evidence that DL-threo dihydrosphingosine and sphingosine are inhibitors of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. We show that DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of ERK. We conclude that DL-threo dihydrosphingosine may represent an important pharmacological cell-permeable agent that may be usefully employed to block smooth muscle cell proliferation.
Original languageEnglish
Pages (from-to)185-186
Number of pages2
JournalBritish Journal of Pharmacology
Volume119
Issue number2
Publication statusPublished - Sep 1996

Keywords

  • animals
  • bradykinin
  • calcium-calmodulin-dependent protein kinases
  • cells, cultured
  • enzyme activation
  • enzyme inhibitors
  • guinea pigs
  • mitogen-activated protein kinase 1
  • mitogen-activated protein kinase 3
  • mitogen-activated protein kinases
  • muscle, smooth
  • platelet-derived growth factor
  • signal transduction
  • sphingosine
  • stimulation, chemical
  • trachea

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