TY - JOUR
T1 - The genus Serratia revisited by genomics
AU - Williams, David J.
AU - Grimont, Patrick A.D.
AU - Cazares, Adrián
AU - Grimont, Francine
AU - Ageron, Elisabeth
AU - Pettigrew, Kerry A.
AU - Cazares, Daniel
AU - Njamkepo, Elisabeth
AU - Weill, François Xavier
AU - Heinz, Eva
AU - Holden, Matthew T.G.
AU - Thomson, Nicholas R.
AU - Coulthurst, Sarah J.
PY - 2022/9/3
Y1 - 2022/9/3
N2 - The genus Serratia has been studied for over a century and includes clinically-important and diverse environmental members. Despite this, there is a paucity of genomic information across the genus and a robust whole genome-based phylogenetic framework is lacking. Here, we have assembled and analysed a representative set of 664 genomes from across the genus, including 215 historic isolates originally used in defining the genus. Phylogenomic analysis of the genus reveals a clearly-defined population structure which displays deep divisions and aligns with ecological niche, as well as striking congruence between historical biochemical phenotyping data and contemporary genomics data. We highlight the genomic, phenotypic and plasmid diversity of Serratia, and provide evidence of different patterns of gene flow across the genus. Our work provides a framework for understanding the emergence of clinical and other lineages of Serratia.
AB - The genus Serratia has been studied for over a century and includes clinically-important and diverse environmental members. Despite this, there is a paucity of genomic information across the genus and a robust whole genome-based phylogenetic framework is lacking. Here, we have assembled and analysed a representative set of 664 genomes from across the genus, including 215 historic isolates originally used in defining the genus. Phylogenomic analysis of the genus reveals a clearly-defined population structure which displays deep divisions and aligns with ecological niche, as well as striking congruence between historical biochemical phenotyping data and contemporary genomics data. We highlight the genomic, phenotypic and plasmid diversity of Serratia, and provide evidence of different patterns of gene flow across the genus. Our work provides a framework for understanding the emergence of clinical and other lineages of Serratia.
KW - phylogenetic framework
KW - Phylogenomic analysis
KW - gene flow
UR - http://www.scopus.com/inward/record.url?scp=85137169808&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-32929-2
DO - 10.1038/s41467-022-32929-2
M3 - Article
C2 - 36057639
AN - SCOPUS:85137169808
SN - 2041-1723
VL - 13
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5195
ER -