The genetic basis of resistance to ostertagia circumcincta in lambs

M.J. Stear, K. Bairden, S.C. Bishop, J. Buitkamp, J.L. Duncan, G. Gettinby, Q.A. McKellar, M. Park

Research output: Contribution to journalArticle

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Abstract

The relationship between Ostertagia (Teladorsagia) circumcincta and sheep is one of the best understoodhost-parasite relationships in any species. The key components of resistance have been quantified, the extent of genetic control has been established for lambs, and methods now exist to breed lambs which will be both more resistant to worms and more productive than unselected lambs. A major gene for resistance has been identified within or around the major histocompatibility complex, and this gene appears to be the strongest yet identified for resistance to any parasite species. The most important mechanisms of resistance are local IgA responses which regulate worm fecundity and immediate hypersensitivity responses which regulate worm burdens. IgA responses develop before effective immediate hypersensitivity responses. Good simulation models now exist to predict, for example, outbreaks of disease and the response of sheep to selection. The challenge now is to use our improved understanding of the population biology to develop even better simulation models and to produce expert systems based on these models which can be used by veterinarians and others to determine optimal procedures for individual farms to control disease and reduce sub-clinical economic losses.
LanguageEnglish
Pages111-119
Number of pages8
JournalVeterinary Journal
Volume154
Issue number2
DOIs
Publication statusPublished - Sep 1997

Fingerprint

Ostertagia
Immediate Hypersensitivity
Teladorsagia circumcincta
immediate hypersensitivity
Immunoglobulin A
Parasites
lambs
Sheep Diseases
Expert Systems
Veterinarians
simulation models
Major Histocompatibility Complex
Genes
Disease Outbreaks
Fertility
sheep
parasites
Sheep
expert systems
genetic resistance

Keywords

  • parasite
  • genetics
  • sheep
  • immunity
  • epidemiology

Cite this

Stear, M. J., Bairden, K., Bishop, S. C., Buitkamp, J., Duncan, J. L., Gettinby, G., ... Park, M. (1997). The genetic basis of resistance to ostertagia circumcincta in lambs. Veterinary Journal, 154(2), 111-119. https://doi.org/10.1016/S1090-0233(97)80049-4
Stear, M.J. ; Bairden, K. ; Bishop, S.C. ; Buitkamp, J. ; Duncan, J.L. ; Gettinby, G. ; McKellar, Q.A. ; Park, M. / The genetic basis of resistance to ostertagia circumcincta in lambs. In: Veterinary Journal. 1997 ; Vol. 154, No. 2. pp. 111-119.
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Stear, MJ, Bairden, K, Bishop, SC, Buitkamp, J, Duncan, JL, Gettinby, G, McKellar, QA & Park, M 1997, 'The genetic basis of resistance to ostertagia circumcincta in lambs' Veterinary Journal, vol. 154, no. 2, pp. 111-119. https://doi.org/10.1016/S1090-0233(97)80049-4

The genetic basis of resistance to ostertagia circumcincta in lambs. / Stear, M.J.; Bairden, K.; Bishop, S.C.; Buitkamp, J.; Duncan, J.L.; Gettinby, G.; McKellar, Q.A.; Park, M.

In: Veterinary Journal, Vol. 154, No. 2, 09.1997, p. 111-119.

Research output: Contribution to journalArticle

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Stear MJ, Bairden K, Bishop SC, Buitkamp J, Duncan JL, Gettinby G et al. The genetic basis of resistance to ostertagia circumcincta in lambs. Veterinary Journal. 1997 Sep;154(2):111-119. https://doi.org/10.1016/S1090-0233(97)80049-4