The future of polar organometallic chemistry written in bio-based solvents and water

Joaquín García-Álvarez, Eva Hevia, Vito Capriati

Research output: Contribution to journalReview articlepeer-review

61 Citations (Scopus)
23 Downloads (Pure)


There is a strong imperative to reduce the release of volatile organic compounds (VOCs) into the environment, and many efforts are currently being made to replace conventional hazardous VOCs in favour of safe, green and bio-renewable reaction media that are not based on crude petroleum. Recent ground-breaking studies from a few laboratories worldwide have shown that both Grignard and (functionalised) organolithium reagents, traditionally handled under strict exclusion of air and humidity and in anhydrous VOCs, can smoothly promote both nucleophilic additions to unsaturated substrates and nucleophilic substitutions in water and other bio-based solvents (glycerol, deep eutectic solvents), competitively with protonolysis, at room temperature and under air. The chemistry of polar organometallics in the above protic media is a complex phenomenon influenced by several factors, and understanding its foundational character is surely stimulating in the perspective of the development of a sustainable organometallic chemistry.
Original languageEnglish
Number of pages11
JournalChemistry - A European Journal
Early online date19 Jun 2018
Publication statusE-pub ahead of print - 19 Jun 2018


  • sustainable chemistry
  • polar organometallics
  • deep eutectic solvents
  • water chemistry
  • solvent effects


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