The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.
- protein sorting
- membrane microdomains
- protein processing, post-translational
- protein sorting signals
- protein transport
- lipid rafts
Greaves, J., Prescott, G. R., Gorleku, O. A., & Chamberlain, L. H. (2009). The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review). Molecular Membrane Biology, 26(1), 67-79. https://doi.org/10.1080/09687680802620351