The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R Prescott, Oforiwa A Gorleku, Luke H Chamberlain

Research output: Contribution to journalLiterature reviewpeer-review

54 Citations (Scopus)


The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.
Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalMolecular Membrane Biology
Issue number1
Publication statusPublished - 2009


  • protein sorting
  • lipoylation
  • membrane microdomains
  • protein processing, post-translational
  • protein sorting signals
  • protein transport
  • proteins
  • palmitoylation
  • lipid rafts

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