The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves; Gerald R Prescott; Oforiwa A Gorleku; Luke H Chamberlain

doi:10.1080/09687680802620351

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R Prescott, Oforiwa A Gorleku, Luke H Chamberlain

Research output: Contribution to journal › Literature review › peer-review

65 Citations (Scopus)

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

Original language	English
Pages (from-to)	67-79
Number of pages	13
Journal	Molecular Membrane Biology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1080/09687680802620351
Publication status	Published - 2009

Keywords

protein sorting
lipoylation
membrane microdomains
protein processing, post-translational
protein sorting signals
protein transport
proteins
palmitoylation
lipid rafts

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10.1080/09687680802620351

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title = "The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)",

abstract = "The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.",

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AU - Gorleku, Oforiwa A

AU - Chamberlain, Luke H

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AB - The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

KW - protein sorting

KW - lipoylation

KW - membrane microdomains

KW - protein processing, post-translational

KW - protein sorting signals

KW - protein transport

KW - proteins

KW - palmitoylation

KW - lipid rafts

U2 - 10.1080/09687680802620351

DO - 10.1080/09687680802620351

M3 - Literature review

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VL - 26

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JO - Molecular Membrane Biology

JF - Molecular Membrane Biology

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ER -

The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Abstract

Keywords

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