The fat controller

roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

Jennifer Greaves, Gerald R Prescott, Oforiwa A Gorleku, Luke H Chamberlain

Research output: Contribution to journalLiterature review

47 Citations (Scopus)

Abstract

The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.
Original languageEnglish
Pages (from-to)67-79
Number of pages13
JournalMolecular Membrane Biology
Volume26
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Lipoylation
Membrane Microdomains
Protein Transport
Fats
Palmitic Acid
Post Translational Protein Processing
Protein Sorting Signals
Cysteine
Membrane Proteins
Amino Acids

Keywords

  • protein sorting
  • lipoylation
  • membrane microdomains
  • protein processing, post-translational
  • protein sorting signals
  • protein transport
  • proteins
  • palmitoylation
  • lipid rafts

Cite this

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title = "The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)",
abstract = "The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.",
keywords = "protein sorting, lipoylation, membrane microdomains, protein processing, post-translational, protein sorting signals, protein transport, proteins, palmitoylation , lipid rafts",
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pages = "67--79",
journal = "Molecular Membrane Biology",
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The fat controller : roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review). / Greaves, Jennifer; Prescott, Gerald R; Gorleku, Oforiwa A; Chamberlain, Luke H.

In: Molecular Membrane Biology, Vol. 26, No. 1, 2009, p. 67-79.

Research output: Contribution to journalLiterature review

TY - JOUR

T1 - The fat controller

T2 - roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review)

AU - Greaves, Jennifer

AU - Prescott, Gerald R

AU - Gorleku, Oforiwa A

AU - Chamberlain, Luke H

PY - 2009

Y1 - 2009

N2 - The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

AB - The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.

KW - protein sorting

KW - lipoylation

KW - membrane microdomains

KW - protein processing, post-translational

KW - protein sorting signals

KW - protein transport

KW - proteins

KW - palmitoylation

KW - lipid rafts

U2 - 10.1080/09687680802620351

DO - 10.1080/09687680802620351

M3 - Literature review

VL - 26

SP - 67

EP - 79

JO - Molecular Membrane Biology

JF - Molecular Membrane Biology

SN - 0968-7688

IS - 1

ER -