Abstract
The effect of receptor desensitization produced by carbachol on the antagonist action of α‐bungarotoxin has been studied in cultured skeletal muscle from chick embryos. In control preparations, α‐bungarotoxin irreversibly blocked depolarization produced by carbachol. However, after receptor desensitization, α‐bungarotoxin was no longer effective in blocking the response to carbachol. It is concluded that desensitization protects cholinoceptors from the action of α‐bungarotoxin.
Original language | English |
---|---|
Pages (from-to) | 456-458 |
Number of pages | 3 |
Journal | British Journal of Pharmacology |
Volume | 51 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 1974 |
Keywords
- acetylcholine
- alpha bungarotoxin
- carbachol
- cholinergic receptor
- drug receptor
- cell culture
- drug antagonism
- in vitro study
- membrane potential