The effect of receptor desensitization on the action of α‐bungarotoxin on cultured skeletal muscle

W. F. DRYDEN, A. L. HARVEY

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3 Citations (Scopus)

Abstract

The effect of receptor desensitization produced by carbachol on the antagonist action of α‐bungarotoxin has been studied in cultured skeletal muscle from chick embryos. In control preparations, α‐bungarotoxin irreversibly blocked depolarization produced by carbachol. However, after receptor desensitization, α‐bungarotoxin was no longer effective in blocking the response to carbachol. It is concluded that desensitization protects cholinoceptors from the action of α‐bungarotoxin.

Original languageEnglish
Pages (from-to)456-458
Number of pages3
JournalBritish Journal of Pharmacology
Volume51
Issue number3
DOIs
Publication statusPublished - 1 Jan 1974

Keywords

  • acetylcholine
  • alpha bungarotoxin
  • carbachol
  • cholinergic receptor
  • drug receptor
  • cell culture
  • drug antagonism
  • in vitro study
  • membrane potential

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