The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

Grahame Busby, Philip Riches, Mary Grant, Simon MacKay

Research output: Contribution to journalMeeting abstract

Abstract

Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

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Collagen
Gels
Mechanical properties
Cell proliferation
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Cell Communication
Cell Proliferation
Water

Keywords

  • cell ingrowth
  • collagen gels
  • cell-matrix interactions
  • tissue engineering scaffolds
  • tissue engineering

Cite this

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title = "The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels",
abstract = "Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5{\%} water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.",
keywords = "cell ingrowth, collagen gels, cell-matrix interactions, tissue engineering scaffolds, tissue engineering",
author = "Grahame Busby and Philip Riches and Mary Grant and Simon MacKay",
year = "2013",
month = "8",
doi = "10.5301/ijao.5000244",
language = "English",
volume = "36",
pages = "567",
journal = "International Journal of Artificial Organs",
issn = "0391-3988",
number = "8",

}

The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels. / Busby, Grahame; Riches, Philip; Grant, Mary; MacKay, Simon.

In: International Journal of Artificial Organs, Vol. 36, No. 8, O106, 08.2013, p. 567.

Research output: Contribution to journalMeeting abstract

TY - JOUR

T1 - The effect of cell ingrowth on the mechanical behaviour of anchored collagen gels

AU - Busby, Grahame

AU - Riches, Philip

AU - Grant, Mary

AU - MacKay, Simon

PY - 2013/8

Y1 - 2013/8

N2 - Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

AB - Collagen gels are often used in studies of cell-matrix interactions and as scaffolds for tissue engineering. However, the effect of cell proliferation on their bulk mechanical properties is still poorly understood. We recently published a method for extracting meaningful mechanical properties from collagen gels of > 99.5% water, using confined compression and biphasic theory (J Biomech 46 (2013) 837). In the present study we used this technique to investigate the effects of cell ingrowth on the transient mechanical behaviour of highly hydrated collagen gels.

KW - cell ingrowth

KW - collagen gels

KW - cell-matrix interactions

KW - tissue engineering scaffolds

KW - tissue engineering

U2 - 10.5301/ijao.5000244

DO - 10.5301/ijao.5000244

M3 - Meeting abstract

VL - 36

SP - 567

JO - International Journal of Artificial Organs

T2 - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

IS - 8

M1 - O106

ER -