The effect of anticoagulants on the distribution of chromium (VI) in blood fractions

G.A. Afolaranmi, J.N.A. Tettey, H. Murray, R.M.D. Meek, M.H. Grant

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate the influence of anticoagulants on the in vitro distribution pattern of hexavalent chromium in blood fractions. Many metallic implants used in orthopaedics are made of stainless steel or cobalt-chromium alloys which contain 18-30% chromium. Hexavalent chromium has been shown to be the predominant form of chromium released following in vivo and in vitro corrosion of these metal implants (Merritt & Brown 1995). Blood chromium levels may be elevated 50-250 times in patients with metal hip implants (Lhotka et al 2003). At physiological pH, hexavalent chromium exists predominantly as the chromate anion and as such can enter cells via non-specific anion channels. The anionic hexavalent chromium diffuses readily through the red blood cell (RBC) membrane and is bound by the haemoglobin probably after its rapid reduction to the cationic trivalent state within the RBC (Gray & Sterling 1950).
LanguageEnglish
PagesA4
JournalJournal of Pharmacy and Pharmacology
Volume59
Issue numberS1
Publication statusPublished - 2007

Fingerprint

Anticoagulants
Chromium
Anions
Erythrocytes
Metals
Chromium Alloys
Chromates
Corrosion
Stainless Steel
Orthopedics
Hip
Hemoglobins
Cell Membrane
chromium hexavalent ion
In Vitro Techniques

Cite this

Afolaranmi, G. A., Tettey, J. N. A., Murray, H., Meek, R. M. D., & Grant, M. H. (2007). The effect of anticoagulants on the distribution of chromium (VI) in blood fractions. Journal of Pharmacy and Pharmacology, 59(S1), A4.
Afolaranmi, G.A. ; Tettey, J.N.A. ; Murray, H. ; Meek, R.M.D. ; Grant, M.H. / The effect of anticoagulants on the distribution of chromium (VI) in blood fractions. In: Journal of Pharmacy and Pharmacology. 2007 ; Vol. 59, No. S1. pp. A4.
@article{b18275d63ea44f63a1002285970d8a7f,
title = "The effect of anticoagulants on the distribution of chromium (VI) in blood fractions",
abstract = "Objectives: To investigate the influence of anticoagulants on the in vitro distribution pattern of hexavalent chromium in blood fractions. Many metallic implants used in orthopaedics are made of stainless steel or cobalt-chromium alloys which contain 18-30{\%} chromium. Hexavalent chromium has been shown to be the predominant form of chromium released following in vivo and in vitro corrosion of these metal implants (Merritt & Brown 1995). Blood chromium levels may be elevated 50-250 times in patients with metal hip implants (Lhotka et al 2003). At physiological pH, hexavalent chromium exists predominantly as the chromate anion and as such can enter cells via non-specific anion channels. The anionic hexavalent chromium diffuses readily through the red blood cell (RBC) membrane and is bound by the haemoglobin probably after its rapid reduction to the cationic trivalent state within the RBC (Gray & Sterling 1950).",
author = "G.A. Afolaranmi and J.N.A. Tettey and H. Murray and R.M.D. Meek and M.H. Grant",
year = "2007",
language = "English",
volume = "59",
pages = "A4",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
number = "S1",

}

Afolaranmi, GA, Tettey, JNA, Murray, H, Meek, RMD & Grant, MH 2007, 'The effect of anticoagulants on the distribution of chromium (VI) in blood fractions' Journal of Pharmacy and Pharmacology, vol. 59, no. S1, pp. A4.

The effect of anticoagulants on the distribution of chromium (VI) in blood fractions. / Afolaranmi, G.A.; Tettey, J.N.A.; Murray, H.; Meek, R.M.D.; Grant, M.H.

In: Journal of Pharmacy and Pharmacology, Vol. 59, No. S1, 2007, p. A4.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of anticoagulants on the distribution of chromium (VI) in blood fractions

AU - Afolaranmi, G.A.

AU - Tettey, J.N.A.

AU - Murray, H.

AU - Meek, R.M.D.

AU - Grant, M.H.

PY - 2007

Y1 - 2007

N2 - Objectives: To investigate the influence of anticoagulants on the in vitro distribution pattern of hexavalent chromium in blood fractions. Many metallic implants used in orthopaedics are made of stainless steel or cobalt-chromium alloys which contain 18-30% chromium. Hexavalent chromium has been shown to be the predominant form of chromium released following in vivo and in vitro corrosion of these metal implants (Merritt & Brown 1995). Blood chromium levels may be elevated 50-250 times in patients with metal hip implants (Lhotka et al 2003). At physiological pH, hexavalent chromium exists predominantly as the chromate anion and as such can enter cells via non-specific anion channels. The anionic hexavalent chromium diffuses readily through the red blood cell (RBC) membrane and is bound by the haemoglobin probably after its rapid reduction to the cationic trivalent state within the RBC (Gray & Sterling 1950).

AB - Objectives: To investigate the influence of anticoagulants on the in vitro distribution pattern of hexavalent chromium in blood fractions. Many metallic implants used in orthopaedics are made of stainless steel or cobalt-chromium alloys which contain 18-30% chromium. Hexavalent chromium has been shown to be the predominant form of chromium released following in vivo and in vitro corrosion of these metal implants (Merritt & Brown 1995). Blood chromium levels may be elevated 50-250 times in patients with metal hip implants (Lhotka et al 2003). At physiological pH, hexavalent chromium exists predominantly as the chromate anion and as such can enter cells via non-specific anion channels. The anionic hexavalent chromium diffuses readily through the red blood cell (RBC) membrane and is bound by the haemoglobin probably after its rapid reduction to the cationic trivalent state within the RBC (Gray & Sterling 1950).

UR - http:dx.doi.org/10.1211/002235707781850159

M3 - Article

VL - 59

SP - A4

JO - Journal of Pharmacy and Pharmacology

T2 - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - S1

ER -