The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

P T Colahan; K A Savage; I R Tebbett; B L Rice; C A Jackson; L Freshwater

doi:10.1111/j.2042-3306.2006.tb05550.x

The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

P T Colahan, K A Savage, I R Tebbett, B L Rice, C A Jackson, L Freshwater

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.

Original language	English
Pages (from-to)	262-266
Number of pages	5
Journal	Equine veterinary journal
Volume	38
Issue number	S36
DOIs	https://doi.org/10.1111/j.2042-3306.2006.tb05550.x
Publication status	Published - Aug 2006

Keywords

adrenergic alpha-agonists
adrenocorticotropic hormone
animals
carbon dioxide
cross-over studies
epinephrine
exercise test
female
guanabenz
heart rate
horses
hydrocortisone
male
norepinephrine
oxygen consumption
physical conditioning
time factors
cortisol
catecholamines

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10.1111/j.2042-3306.2006.tb05550.x

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title = "The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses",

abstract = "Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.",

keywords = "adrenergic alpha-agonists, adrenocorticotropic hormone, animals, carbon dioxide, cross-over studies, epinephrine, exercise test, female, guanabenz, heart rate, horses, hydrocortisone, male, norepinephrine, oxygen consumption, physical conditioning, time factors, cortisol, catecholamines",

author = "Colahan, \{P T\} and Savage, \{K A\} and Tebbett, \{I R\} and Rice, \{B L\} and Jackson, \{C A\} and L Freshwater",

year = "2006",

month = aug,

doi = "10.1111/j.2042-3306.2006.tb05550.x",

language = "English",

volume = "38",

pages = "262--266",

journal = "Equine veterinary journal",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

AU - Colahan, P T

AU - Savage, K A

AU - Tebbett, I R

AU - Rice, B L

AU - Jackson, C A

AU - Freshwater, L

PY - 2006/8

Y1 - 2006/8

N2 - Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.

AB - Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.

KW - adrenergic alpha-agonists

KW - adrenocorticotropic hormone

KW - animals

KW - carbon dioxide

KW - cross-over studies

KW - epinephrine

KW - exercise test

KW - female

KW - guanabenz

KW - heart rate

KW - horses

KW - hydrocortisone

KW - male

KW - norepinephrine

KW - oxygen consumption

KW - physical conditioning

KW - time factors

KW - cortisol

KW - catecholamines

U2 - 10.1111/j.2042-3306.2006.tb05550.x

DO - 10.1111/j.2042-3306.2006.tb05550.x

M3 - Article

C2 - 17402429

VL - 38

SP - 262

EP - 266

JO - Equine veterinary journal

JF - Equine veterinary journal

IS - S36

ER -

The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

Abstract

Keywords

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