The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

P T Colahan, K A Savage, I R Tebbett, B L Rice, C A Jackson, L Freshwater

Research output: Contribution to journalArticle

Abstract

Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.
Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalEquine veterinary journal
Volume38
Issue numberS36
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Guanabenz
Adrenergic Neurons
Adrenergic Agents
Antihypertensive Agents
Horses
exercise
horses
antihypertensive agents
Brain
neurons
brain

Keywords

  • adrenergic alpha-agonists
  • adrenocorticotropic hormone
  • animals
  • carbon dioxide
  • cross-over studies
  • epinephrine
  • exercise test
  • female
  • guanabenz
  • heart rate
  • horses
  • hydrocortisone
  • male
  • norepinephrine
  • oxygen consumption
  • physical conditioning
  • time factors
  • cortisol
  • catecholamines

Cite this

Colahan, P T ; Savage, K A ; Tebbett, I R ; Rice, B L ; Jackson, C A ; Freshwater, L. / The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses. In: Equine veterinary journal. 2006 ; Vol. 38, No. S36. pp. 262-266.
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The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses. / Colahan, P T; Savage, K A; Tebbett, I R; Rice, B L; Jackson, C A; Freshwater, L.

In: Equine veterinary journal, Vol. 38, No. S36, 08.2006, p. 262-266.

Research output: Contribution to journalArticle

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AU - Jackson, C A

AU - Freshwater, L

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KW - exercise test

KW - female

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KW - heart rate

KW - horses

KW - hydrocortisone

KW - male

KW - norepinephrine

KW - oxygen consumption

KW - physical conditioning

KW - time factors

KW - cortisol

KW - catecholamines

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