The effect of adrenergic suppression induced by guanabenz administration on exercising thoroughbred horses

P T Colahan, K A Savage, I R Tebbett, B L Rice, C A Jackson, L Freshwater

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1 Citation (Scopus)


Adrenergic activity accompanies intense exercise and mediates physiological and metabolic responses to exercise. Guanabenz, an antihypertensive drug marketed for human usage, depresses brain vasomotor and cardioaccelerator centres, blocks peripherally adrenergic neurons and is reportedly used as a calming agent in horses but little is known of its effects in the species.
Original languageEnglish
Pages (from-to)262-266
Number of pages5
JournalEquine veterinary journal
Issue numberS36
Publication statusPublished - Aug 2006


  • adrenergic alpha-agonists
  • adrenocorticotropic hormone
  • animals
  • carbon dioxide
  • cross-over studies
  • epinephrine
  • exercise test
  • female
  • guanabenz
  • heart rate
  • horses
  • hydrocortisone
  • male
  • norepinephrine
  • oxygen consumption
  • physical conditioning
  • time factors
  • cortisol
  • catecholamines

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