The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA)

Lauren E. Connor; Amit Delori; Ian B. Hutchison; Niamh Nic Daeid; Oliver B. Sutcliffe; Iain D. H. Oswald

doi:10.1107/S2052520614026389

The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA)

Lauren E. Connor, Amit Delori, Ian B. Hutchison, Niamh Nic Daeid, Oliver B. Sutcliffe, Iain D. H. Oswald

Strathclyde Institute Of Pharmacy And Biomedical Sciences

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Abstract

MDMA (3,4-methylenedioxymethamphetamine) is a Class A substance that is usually found in a tableted form. It is only observed in one orthorhombic polymorph under ambient conditions. It shows slight positional disorder around the methlyenedioxy ring which persists during compression up to 6.66 GPa. The crystal quality deteriorates above 6.66 GPa where the hydrostatic limit of the pressure-transmitting medium is exceeded. The structure undergoes anisotropic compression with the a-axis compressing the greatest (12% cf. 4 and 10% for the b- and c-axes, respectively). This is due to the pattern of the hydrogen bonding which acts like a spring and allows the compression along this direction.

Original language	English
Pages (from-to)	3-9
Number of pages	6
Journal	Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials
Volume	71
Issue number	1
DOIs	https://doi.org/10.1107/S2052520614026389
Publication status	Published - 2 Feb 2015

Keywords

ecstasy
compression studies
MDMA tablets

Access to Document

10.1107/S2052520614026389

Connor-etal-ACSB-2015-The- ecstasy-and-the-agony-compression-studiesAccepted author manuscript, 1.8 MB

Cite this

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abstract = "MDMA (3,4-methylenedioxymethamphetamine) is a Class A substance that is usually found in a tableted form. It is only observed in one orthorhombic polymorph under ambient conditions. It shows slight positional disorder around the methlyenedioxy ring which persists during compression up to 6.66 GPa. The crystal quality deteriorates above 6.66 GPa where the hydrostatic limit of the pressure-transmitting medium is exceeded. The structure undergoes anisotropic compression with the a-axis compressing the greatest (12\% cf. 4 and 10\% for the b- and c-axes, respectively). This is due to the pattern of the hydrogen bonding which acts like a spring and allows the compression along this direction.",

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AU - Sutcliffe, Oliver B.

AU - Oswald, Iain D. H.

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N2 - MDMA (3,4-methylenedioxymethamphetamine) is a Class A substance that is usually found in a tableted form. It is only observed in one orthorhombic polymorph under ambient conditions. It shows slight positional disorder around the methlyenedioxy ring which persists during compression up to 6.66 GPa. The crystal quality deteriorates above 6.66 GPa where the hydrostatic limit of the pressure-transmitting medium is exceeded. The structure undergoes anisotropic compression with the a-axis compressing the greatest (12% cf. 4 and 10% for the b- and c-axes, respectively). This is due to the pattern of the hydrogen bonding which acts like a spring and allows the compression along this direction.

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The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA)

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The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA)

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