The Ecstasy and the agony; compression studies of 3,4-methylenedioxymethamphetamine (MDMA)

Lauren E. Connor, Amit Delori, Ian B. Hutchison, Niamh Nic Daeid, Oliver B. Sutcliffe, Iain D. H. Oswald

Research output: Contribution to journalArticle

1 Citation (Scopus)
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Abstract

MDMA (3,4-methylenedioxymethamphetamine) is a Class A substance that is usually found in a tableted form. It is only observed in one orthorhombic polymorph under ambient conditions. It shows slight positional disorder around the methlyenedioxy ring which persists during compression up to 6.66 GPa. The crystal quality deteriorates above 6.66 GPa where the hydrostatic limit of the pressure-transmitting medium is exceeded. The structure undergoes anisotropic compression with the a-axis compressing the greatest (12% cf. 4 and 10% for the b- and c-axes, respectively). This is due to the pattern of the hydrogen bonding which acts like a spring and allows the compression along this direction.
Original languageEnglish
Pages (from-to)3-9
Number of pages6
JournalActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials
Volume71
Issue number1
DOIs
Publication statusPublished - 2 Feb 2015

Keywords

  • ecstasy
  • compression studies
  • MDMA tablets

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