The diversity-oriented synthesis of pteridines—achievements and potential for development

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to prepare designed relatives of the natural cofactors for use as potential drugs or biological probes. Recently, diversity-oriented synthesis has become a particularly powerful and versatile approach to the synthesis of pteridines and related heterocyclic compounds. This article describes and discusses available methods using radical, electrophilic, nucleophilic, and organometal mediated substitution reactions.
LanguageEnglish
Pages283-299
Number of pages17
JournalIUBMB Life
Volume65
Issue number4
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Pteridines
Heterocyclic Compounds
Substitution reactions
Pharmaceutical Preparations

Keywords

  • pteridine
  • pteridine folate
  • tetrahydrofolate
  • tetrahydrobiopterin
  • radical substitution
  • nucleophilic substitution
  • organometal mediated coupling
  • diversity-oriented synthesis

Cite this

@article{bad74999fedc4538a6ae834c5c0e1470,
title = "The diversity-oriented synthesis of pteridines—achievements and potential for development",
abstract = "The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to prepare designed relatives of the natural cofactors for use as potential drugs or biological probes. Recently, diversity-oriented synthesis has become a particularly powerful and versatile approach to the synthesis of pteridines and related heterocyclic compounds. This article describes and discusses available methods using radical, electrophilic, nucleophilic, and organometal mediated substitution reactions.",
keywords = "pteridine, pteridine folate, tetrahydrofolate, tetrahydrobiopterin, radical substitution, nucleophilic substitution, organometal mediated coupling, diversity-oriented synthesis",
author = "Colin Suckling",
year = "2013",
month = "4",
doi = "10.1002/iub.1148",
language = "English",
volume = "65",
pages = "283--299",
journal = "IUBMB Life",
issn = "1521-6543",
number = "4",

}

The diversity-oriented synthesis of pteridines—achievements and potential for development. / Suckling, Colin.

In: IUBMB Life, Vol. 65, No. 4, 04.2013, p. 283-299 .

Research output: Contribution to journalArticle

TY - JOUR

T1 - The diversity-oriented synthesis of pteridines—achievements and potential for development

AU - Suckling, Colin

PY - 2013/4

Y1 - 2013/4

N2 - The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to prepare designed relatives of the natural cofactors for use as potential drugs or biological probes. Recently, diversity-oriented synthesis has become a particularly powerful and versatile approach to the synthesis of pteridines and related heterocyclic compounds. This article describes and discusses available methods using radical, electrophilic, nucleophilic, and organometal mediated substitution reactions.

AB - The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines. In order to investigate the latter, versatile synthetic methods are required to prepare designed relatives of the natural cofactors for use as potential drugs or biological probes. Recently, diversity-oriented synthesis has become a particularly powerful and versatile approach to the synthesis of pteridines and related heterocyclic compounds. This article describes and discusses available methods using radical, electrophilic, nucleophilic, and organometal mediated substitution reactions.

KW - pteridine

KW - pteridine folate

KW - tetrahydrofolate

KW - tetrahydrobiopterin

KW - radical substitution

KW - nucleophilic substitution

KW - organometal mediated coupling

KW - diversity-oriented synthesis

UR - http://www.scopus.com/inward/record.url?scp=84875343730&partnerID=8YFLogxK

U2 - 10.1002/iub.1148

DO - 10.1002/iub.1148

M3 - Article

VL - 65

SP - 283

EP - 299

JO - IUBMB Life

T2 - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 4

ER -