The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits

Sophie M. Bertrand^*, Nicolas Ancellin, Benjamin Beaufils, Ryan P. Bingham, Jennifer A. Borthwick, Anne Bénédicte Boullay, Eric Boursier, Paul S. Carter, Chun Wa Chung, Ian Churcher, Nerina Dodic, Marie Hélène Fouchet, Charlène Fournier, Peter L. Francis, Laura A. Gummer, Kenny Herry, Andrew Hobbs, Clare I. Hobbs, Paul Homes, Craig JamiesonEdwige Nicodeme, Stephen D. Pickett, Iain H. Reid, Graham L. Simpson, Lisa A. Sloan, Sarah E. Smith, Donald O N Somers, Claus Spitzfaden, Colin J. Suckling, Klara Valko, Yoshiaki Washio, Robert J. YoungShow 12 moreShow less