The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration

J.A. Hunt, J.T. Callaghan, C.J. Sutcliffe, R.H. Morgan, B. Halford, R.A. Black

    Research output: Contribution to journalArticle

    35 Citations (Scopus)

    Abstract

    Improved fixation and increased longevity are still important performance criteria in the development of orthopaedic prostheses. The osseointegration of a series of previous termimplant designs made of conventional cobalt-chromium alloy was investigated, the shape of each implant being the critical variable. The shape was defined by computer-aided design with a view to maximising interdigitation of new bone with the implant. Two different process routes, conventional casting and selective laser sintering were employed, each process yielded implants that had identical surface topology but different microstructures. Hydroxyapatite (HA) was used to coat some samples by plasma spraying. Bone formation associated with each implant design was delineated through the administration of fluorescent vital dyes at three time points following their implantation into New Zealand white rabbits. After one month, specimens were harvested, resin embedded, serial sectioned and examined under fluorescent light microscopy. The amount of bone growth was quantified using image analysis. Plasma spray HA-coated samples promoted better osteogenesis and integration than uncoated samples. The extent of bone growth associated with identically shaped specimens fabricated by the SLS route was markedly greater, attributed to the microstructure of these implants.
    LanguageEnglish
    Pages5890-5897
    Number of pages7
    JournalBiomaterials
    Volume26
    Issue number29
    DOIs
    Publication statusPublished - 2005

    Fingerprint

    Osseointegration
    Computer-Aided Design
    Bone Development
    Surface topography
    Computer aided manufacturing
    Durapatite
    Osteogenesis
    Computer aided design
    Bone
    Chromium Alloys
    Fluorescent Dyes
    Hydroxyapatite
    Prostheses and Implants
    Orthopedics
    Microscopy
    Lasers
    Rabbits
    Light
    Cobalt alloys
    Bone and Bones

    Keywords

    • athroplasty
    • osteoconduction
    • cobalt
    • lasers
    • hydroxyapatite coating
    • rapid prototyping

    Cite this

    Hunt, J.A. ; Callaghan, J.T. ; Sutcliffe, C.J. ; Morgan, R.H. ; Halford, B. ; Black, R.A. / The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration. In: Biomaterials. 2005 ; Vol. 26, No. 29. pp. 5890-5897.
    @article{11bfe1b1bf7a4ca0bad95e4da2e02186,
    title = "The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration",
    abstract = "Improved fixation and increased longevity are still important performance criteria in the development of orthopaedic prostheses. The osseointegration of a series of previous termimplant designs made of conventional cobalt-chromium alloy was investigated, the shape of each implant being the critical variable. The shape was defined by computer-aided design with a view to maximising interdigitation of new bone with the implant. Two different process routes, conventional casting and selective laser sintering were employed, each process yielded implants that had identical surface topology but different microstructures. Hydroxyapatite (HA) was used to coat some samples by plasma spraying. Bone formation associated with each implant design was delineated through the administration of fluorescent vital dyes at three time points following their implantation into New Zealand white rabbits. After one month, specimens were harvested, resin embedded, serial sectioned and examined under fluorescent light microscopy. The amount of bone growth was quantified using image analysis. Plasma spray HA-coated samples promoted better osteogenesis and integration than uncoated samples. The extent of bone growth associated with identically shaped specimens fabricated by the SLS route was markedly greater, attributed to the microstructure of these implants.",
    keywords = "athroplasty, osteoconduction, cobalt, lasers, hydroxyapatite coating, rapid prototyping",
    author = "J.A. Hunt and J.T. Callaghan and C.J. Sutcliffe and R.H. Morgan and B. Halford and R.A. Black",
    year = "2005",
    doi = "10.1016/j.biomaterials.2005.03.004",
    language = "English",
    volume = "26",
    pages = "5890--5897",
    journal = "Biomaterials",
    issn = "0142-9612",
    number = "29",

    }

    The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration. / Hunt, J.A.; Callaghan, J.T.; Sutcliffe, C.J.; Morgan, R.H.; Halford, B.; Black, R.A.

    In: Biomaterials, Vol. 26, No. 29, 2005, p. 5890-5897.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - The design and production of Co-Cr alloy implants with controlled surface topography by CAD-CAM method and their effects on osseointegration

    AU - Hunt, J.A.

    AU - Callaghan, J.T.

    AU - Sutcliffe, C.J.

    AU - Morgan, R.H.

    AU - Halford, B.

    AU - Black, R.A.

    PY - 2005

    Y1 - 2005

    N2 - Improved fixation and increased longevity are still important performance criteria in the development of orthopaedic prostheses. The osseointegration of a series of previous termimplant designs made of conventional cobalt-chromium alloy was investigated, the shape of each implant being the critical variable. The shape was defined by computer-aided design with a view to maximising interdigitation of new bone with the implant. Two different process routes, conventional casting and selective laser sintering were employed, each process yielded implants that had identical surface topology but different microstructures. Hydroxyapatite (HA) was used to coat some samples by plasma spraying. Bone formation associated with each implant design was delineated through the administration of fluorescent vital dyes at three time points following their implantation into New Zealand white rabbits. After one month, specimens were harvested, resin embedded, serial sectioned and examined under fluorescent light microscopy. The amount of bone growth was quantified using image analysis. Plasma spray HA-coated samples promoted better osteogenesis and integration than uncoated samples. The extent of bone growth associated with identically shaped specimens fabricated by the SLS route was markedly greater, attributed to the microstructure of these implants.

    AB - Improved fixation and increased longevity are still important performance criteria in the development of orthopaedic prostheses. The osseointegration of a series of previous termimplant designs made of conventional cobalt-chromium alloy was investigated, the shape of each implant being the critical variable. The shape was defined by computer-aided design with a view to maximising interdigitation of new bone with the implant. Two different process routes, conventional casting and selective laser sintering were employed, each process yielded implants that had identical surface topology but different microstructures. Hydroxyapatite (HA) was used to coat some samples by plasma spraying. Bone formation associated with each implant design was delineated through the administration of fluorescent vital dyes at three time points following their implantation into New Zealand white rabbits. After one month, specimens were harvested, resin embedded, serial sectioned and examined under fluorescent light microscopy. The amount of bone growth was quantified using image analysis. Plasma spray HA-coated samples promoted better osteogenesis and integration than uncoated samples. The extent of bone growth associated with identically shaped specimens fabricated by the SLS route was markedly greater, attributed to the microstructure of these implants.

    KW - athroplasty

    KW - osteoconduction

    KW - cobalt

    KW - lasers

    KW - hydroxyapatite coating

    KW - rapid prototyping

    UR - http://dx.doi.org/10.1016/j.biomaterials.2005.03.004

    U2 - 10.1016/j.biomaterials.2005.03.004

    DO - 10.1016/j.biomaterials.2005.03.004

    M3 - Article

    VL - 26

    SP - 5890

    EP - 5897

    JO - Biomaterials

    T2 - Biomaterials

    JF - Biomaterials

    SN - 0142-9612

    IS - 29

    ER -