The chemical stability of admixtures of injectable corticosteroid and local anaesthetics

D.G. Watson, S. Husain, S. Brennan, J. Baird, D. Finlayson

Research output: Contribution to journalArticle

Abstract

Intra-articular and soft tissue instillation of depot corticosteroids is used as an effective adjunct in managing rheumatoid arthritis, osteoarthritis and other connective tissue conditions. It is common practice to mix the steroid with a local anaesthetic agent prior to administration. The stability of methyl prednisolone when mixed with lidocaine has been assessed, however there is no evidence in the literature regarding the pharmacological stability of triamcinolone acetonide following admixture. Hypothesis: To determine the stability of admixture of injectable corticosteroid and local anaesthetic prior to injection in patients with arthritic conditions. Study design: Original laboratory based analysis. High performance liquid chromatographic (HPLC) analysis was used to assess the stability of combinations of triamcinolone and hydrocortisone when mixed with combinations of lignocaine and bupivacaine. Results: The results show that the combinations are stable when mixed together as judged by our pharmaceutical analysis. These results support the continued use of these products in combination for safe use in clinical practice. Clinical relevance: We have shown that it is safe practice to mix these two components prior to patient administration.
LanguageEnglish
Pages81-83
Number of pages2
JournalCME Orthopaedics
Volume4
Issue number3
Publication statusPublished - 2007

Fingerprint

Lidocaine
Local Anesthetics
Adrenal Cortex Hormones
Triamcinolone
Triamcinolone Acetonide
Injections
Bupivacaine
Prednisolone
Osteoarthritis
Connective Tissue
Arthritis
Anesthetics
Hydrocortisone
Rheumatoid Arthritis
Joints
Steroids
High Pressure Liquid Chromatography
Pharmacology
Pharmaceutical Preparations

Keywords

  • chemical stability
  • admixtures
  • injectable corticosteroid
  • alocal anaesthetics
  • pharmacology

Cite this

Watson, D. G., Husain, S., Brennan, S., Baird, J., & Finlayson, D. (2007). The chemical stability of admixtures of injectable corticosteroid and local anaesthetics. CME Orthopaedics, 4(3), 81-83.
Watson, D.G. ; Husain, S. ; Brennan, S. ; Baird, J. ; Finlayson, D. / The chemical stability of admixtures of injectable corticosteroid and local anaesthetics. In: CME Orthopaedics. 2007 ; Vol. 4, No. 3. pp. 81-83.
@article{012b4144f94f48d3b0f4b7cc79173f94,
title = "The chemical stability of admixtures of injectable corticosteroid and local anaesthetics",
abstract = "Intra-articular and soft tissue instillation of depot corticosteroids is used as an effective adjunct in managing rheumatoid arthritis, osteoarthritis and other connective tissue conditions. It is common practice to mix the steroid with a local anaesthetic agent prior to administration. The stability of methyl prednisolone when mixed with lidocaine has been assessed, however there is no evidence in the literature regarding the pharmacological stability of triamcinolone acetonide following admixture. Hypothesis: To determine the stability of admixture of injectable corticosteroid and local anaesthetic prior to injection in patients with arthritic conditions. Study design: Original laboratory based analysis. High performance liquid chromatographic (HPLC) analysis was used to assess the stability of combinations of triamcinolone and hydrocortisone when mixed with combinations of lignocaine and bupivacaine. Results: The results show that the combinations are stable when mixed together as judged by our pharmaceutical analysis. These results support the continued use of these products in combination for safe use in clinical practice. Clinical relevance: We have shown that it is safe practice to mix these two components prior to patient administration.",
keywords = "chemical stability, admixtures, injectable corticosteroid, alocal anaesthetics, pharmacology",
author = "D.G. Watson and S. Husain and S. Brennan and J. Baird and D. Finlayson",
year = "2007",
language = "English",
volume = "4",
pages = "81--83",
journal = "CME Orthopaedics",
issn = "1367-8957",
publisher = "Rila Publications Ltd",
number = "3",

}

Watson, DG, Husain, S, Brennan, S, Baird, J & Finlayson, D 2007, 'The chemical stability of admixtures of injectable corticosteroid and local anaesthetics' CME Orthopaedics, vol. 4, no. 3, pp. 81-83.

The chemical stability of admixtures of injectable corticosteroid and local anaesthetics. / Watson, D.G.; Husain, S.; Brennan, S.; Baird, J.; Finlayson, D.

In: CME Orthopaedics, Vol. 4, No. 3, 2007, p. 81-83.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The chemical stability of admixtures of injectable corticosteroid and local anaesthetics

AU - Watson, D.G.

AU - Husain, S.

AU - Brennan, S.

AU - Baird, J.

AU - Finlayson, D.

PY - 2007

Y1 - 2007

N2 - Intra-articular and soft tissue instillation of depot corticosteroids is used as an effective adjunct in managing rheumatoid arthritis, osteoarthritis and other connective tissue conditions. It is common practice to mix the steroid with a local anaesthetic agent prior to administration. The stability of methyl prednisolone when mixed with lidocaine has been assessed, however there is no evidence in the literature regarding the pharmacological stability of triamcinolone acetonide following admixture. Hypothesis: To determine the stability of admixture of injectable corticosteroid and local anaesthetic prior to injection in patients with arthritic conditions. Study design: Original laboratory based analysis. High performance liquid chromatographic (HPLC) analysis was used to assess the stability of combinations of triamcinolone and hydrocortisone when mixed with combinations of lignocaine and bupivacaine. Results: The results show that the combinations are stable when mixed together as judged by our pharmaceutical analysis. These results support the continued use of these products in combination for safe use in clinical practice. Clinical relevance: We have shown that it is safe practice to mix these two components prior to patient administration.

AB - Intra-articular and soft tissue instillation of depot corticosteroids is used as an effective adjunct in managing rheumatoid arthritis, osteoarthritis and other connective tissue conditions. It is common practice to mix the steroid with a local anaesthetic agent prior to administration. The stability of methyl prednisolone when mixed with lidocaine has been assessed, however there is no evidence in the literature regarding the pharmacological stability of triamcinolone acetonide following admixture. Hypothesis: To determine the stability of admixture of injectable corticosteroid and local anaesthetic prior to injection in patients with arthritic conditions. Study design: Original laboratory based analysis. High performance liquid chromatographic (HPLC) analysis was used to assess the stability of combinations of triamcinolone and hydrocortisone when mixed with combinations of lignocaine and bupivacaine. Results: The results show that the combinations are stable when mixed together as judged by our pharmaceutical analysis. These results support the continued use of these products in combination for safe use in clinical practice. Clinical relevance: We have shown that it is safe practice to mix these two components prior to patient administration.

KW - chemical stability

KW - admixtures

KW - injectable corticosteroid

KW - alocal anaesthetics

KW - pharmacology

UR - http://www.rila.co.uk/

M3 - Article

VL - 4

SP - 81

EP - 83

JO - CME Orthopaedics

T2 - CME Orthopaedics

JF - CME Orthopaedics

SN - 1367-8957

IS - 3

ER -