The cardioprotective role of small heat shock protein 20

Tamara Martin; Susan Currie; George Baillie

doi:10.1042/BST20130272

The cardioprotective role of small heat shock protein 20

Tamara Martin, Susan Currie, George Baillie

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The small HSP (heat-shock protein) HSP20 is a molecular chaperone that is transiently up-regulated in response to cellular stress/damage. Although ubiquitously expressed in various tissues, it is most highly expressed in skeletal, cardiac and smooth muscle. Phosphorylation at Ser16 by PKA (cAMP-dependent protein kinase) is essential for HSP20 to confer its protective qualities. HSP20 and its phosphorylation have been implicated in a variety of pathophysiological processes, but most prominently cardiovascular disease. A wealth of knowledge of the importance of HSP20 in contractile function and cardioprotection has been gained over the last decade. The present mini-review highlights more recent findings illustrating the cardioprotective properties of HSP20 and its potential as a therapeutic agent.

Original language	English
Pages (from-to)	270-273
Number of pages	4
Journal	Biochemical Society Transactions
Volume	42
Issue number	2
DOIs	https://doi.org/10.1042/BST20130272
Publication status	Published - Apr 2014

Keywords

cAMP
cardioprotection
heat-shock protein 20 (HSP20)
peptide array
phosphodiesterase type 4 (PDE4)

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10.1042/BST20130272

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AU - Currie, Susan

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AB - The small HSP (heat-shock protein) HSP20 is a molecular chaperone that is transiently up-regulated in response to cellular stress/damage. Although ubiquitously expressed in various tissues, it is most highly expressed in skeletal, cardiac and smooth muscle. Phosphorylation at Ser16 by PKA (cAMP-dependent protein kinase) is essential for HSP20 to confer its protective qualities. HSP20 and its phosphorylation have been implicated in a variety of pathophysiological processes, but most prominently cardiovascular disease. A wealth of knowledge of the importance of HSP20 in contractile function and cardioprotection has been gained over the last decade. The present mini-review highlights more recent findings illustrating the cardioprotective properties of HSP20 and its potential as a therapeutic agent.

KW - cAMP

KW - cardioprotection

KW - heat-shock protein 20 (HSP20)

KW - peptide array

KW - phosphodiesterase type 4 (PDE4)

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JF - Biochemical Society Transactions

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