Abstract
The brucine N-oxide-mediated asymmetric Pauson–Khand reaction has been further investigated. It was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes. The studies also revealed that when acetone or 1,2-dimethoxyethane is used as the reaction solvent, enhanced levels of enantioselectivity, up to an enantiomeric ratio of 11:89, are achieved.
Original language | English |
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Pages (from-to) | 3229-3233 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 17 |
DOIs | |
Publication status | Published - 22 Apr 2000 |
Keywords
- amine N-oxides
- asymmetric synthesis
- cobalt and compounds
- cyclopentenones
- Pauson–Khand reactions