The brucine N-oxide-promoted asymmetric Pauson–Khand reaction

William J Kerr, David M Lindsay, Elaine M Rankin, James S Scott, Stephen P Watson

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48 Citations (Scopus)


The brucine N-oxide-mediated asymmetric Pauson–Khand reaction has been further investigated. It was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes. The studies also revealed that when acetone or 1,2-dimethoxyethane is used as the reaction solvent, enhanced levels of enantioselectivity, up to an enantiomeric ratio of 11:89, are achieved.
Original languageEnglish
Pages (from-to)3229-3233
Number of pages5
JournalTetrahedron Letters
Issue number17
Publication statusPublished - 22 Apr 2000


  • amine N-oxides
  • asymmetric synthesis
  • cobalt and compounds
  • cyclopentenones
  • Pauson–Khand reactions


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