The brucine N-oxide-promoted asymmetric Pauson–Khand reaction

William J Kerr, David M Lindsay, Elaine M Rankin, James S Scott, Stephen P Watson

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

The brucine N-oxide-mediated asymmetric Pauson–Khand reaction has been further investigated. It was found that the best levels of enantioselection were obtained with substituted propargylic alcohol complexes. The studies also revealed that when acetone or 1,2-dimethoxyethane is used as the reaction solvent, enhanced levels of enantioselectivity, up to an enantiomeric ratio of 11:89, are achieved.
Original languageEnglish
Pages (from-to)3229-3233
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number17
DOIs
Publication statusPublished - 22 Apr 2000

Keywords

  • amine N-oxides
  • asymmetric synthesis
  • cobalt and compounds
  • cyclopentenones
  • Pauson–Khand reactions

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