The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery

Darren Michael Moss, Paul Curley, Hannah Kinvig, Clare Hoskins, Andrew Owen

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being investigated. The mucosal surface of the gastrointestinal tract is capable of trapping and eliminating large particles and pathogens as part of the natural defences of the body, it is becoming clearer that nanoformulation properties such as particle size, charge, and shape, as well as mucous properties such as viscoelasticity, thickness, density, and turn-over time are all relevant to these interactions. However, progress has been slow to utilise this information to produce effective mucous-penetrating particles. Areas covered: This review focuses on delivery method of nanomedicines both into and across the gastrointestinal mucosal surface, and aims to summarise the biological barriers that exist to successful oral nanomedicine delivery and how these barriers may be investigated and overcome. Expert commentary: Despite successes in the laboratory, no nanotechnology-enabled products are currently in clinical use which either specifically target the intestinal mucous surface or cross the epithelial barrier intact. New nanomedicine-based treatments of local diseases (intestinal cancer, inflammation, infection) and systemic diseases are advancing towards clinical use, and offer genuine opportunities to improve therapy.
Original languageEnglish
Pages (from-to)223-236
Number of pages43
JournalExpert Review of Gastroenterology & Hepatology
Volume12
Issue number3
DOIs
Publication statusPublished - 8 Nov 2017

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Keywords

  • nanomedicine
  • mucoadhesion
  • targeted drug delivery
  • mucous
  • intestine

Cite this

Moss, D. M., Curley, P., Kinvig, H., Hoskins, C., & Owen, A. (2017). The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery. Expert Review of Gastroenterology & Hepatology , 12(3), 223-236 . https://doi.org/10.1080/17474124.2018.1399794