The back and forth of dendritic plasticity

Stephen R Williams, Christian Wozny, Simon J Mitchell

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Synapses are located throughout the often-elaborate dendritic tree of central neurons. Hebbian models of plasticity require temporal association between synaptic input and neuronal output to produce long-term potentiation of excitatory transmission. Recent studies have highlighted how active dendritic spiking mechanisms control this association. Here, we review new work showing that associative synaptic plasticity can be generated without neuronal output and that the interplay between neuronal architecture and the active electrical properties of the dendritic tree regulates synaptic plasticity.

Original languageEnglish
Pages (from-to)947-953
Number of pages7
JournalNeuron
Volume56
Issue number6
DOIs
Publication statusPublished - 20 Dec 2007

Keywords

  • animals
  • dendrites
  • models, biological
  • neuronal plasticity
  • neurons
  • synapses

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