The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments

Jéssica Rodríguez, Jesús Mosquera, Jose R. Couceiro, M. Eugenio Vázquez, José L. Mascareñas

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We report the development of chimeric DNA binding peptides comprising a DNA binding fragment of natural transcription factors (the basic region of a bZIP protein or a monomeric zinc finger module) and an AT-Hook peptide motif. The resulting peptide conjugates display high DNA affinity and excellent sequence selectivity. Furthermore, the AT-Hook motif also favors the cell internalization of the conjugates.

Original languageEnglish
Pages (from-to)4767-4771
Number of pages5
JournalChemical Science
Volume6
Issue number8
DOIs
Publication statusPublished - 1 Aug 2015

Keywords

  • DNA binding
  • chimeric DNA binding peptides
  • AT-Hook motif

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