The application of metabolomic profiling to the effects of physical activity

Evangelia Daskalaki, Chris Easton, David G. Watson

Research output: Contribution to journalArticle

Abstract

Physical activity and exercise are potent lifestyle interventions for the reduction of several psychosomatic risks, including cardiovascular disease, diabetes and mild-to-moderate depression. The current review describes the studies which have utilised a metabolomics/ metabolite profiling approach in combination with exercise in the period between 1999-2014 in predominantly healthy subjects (N:64) and in a smaller subset of patient cohorts (N:10) between 2011-2014. A broad range of intervention types were used in both healthy and patient cohorts with varying exercise regimes with or without supplement use. Effects on purine metabolism, which have been known for over 40 years, were by far the most well-cited and persistent finding. Other reported effects included observations of: glucocorticoid and androgen metabolism, glycolysis and Krebs cycle, gluconeogenesis, fatty acid metabolism, fatty acid oxidation and pantothenic acid, amino acid oxidation, tryptophan metabolism and effects on microbiome metabolites. The discussion section draws observations from the very disparate studies together and links them to the general aspects of human metabolism.
LanguageEnglish
Pages233-263
Number of pages31
JournalCurrent Metabolomics
Volume2
Issue number4
DOIs
Publication statusPublished - 2014

Fingerprint

Metabolomics
Exercise
Fatty Acids
Pantothenic Acid
Citric Acid Cycle
Gluconeogenesis
Microbiota
Glycolysis
Tryptophan
Glucocorticoids
Androgens
Life Style
Healthy Volunteers
Cardiovascular Diseases
Depression
Amino Acids

Keywords

  • human
  • metabolomics
  • microbiome
  • physical activity
  • purine metabolism
  • training effect

Cite this

Daskalaki, Evangelia ; Easton, Chris ; Watson, David G. / The application of metabolomic profiling to the effects of physical activity. In: Current Metabolomics. 2014 ; Vol. 2, No. 4. pp. 233-263.
@article{39dc18e456564f1a8cd17642cd3cd68f,
title = "The application of metabolomic profiling to the effects of physical activity",
abstract = "Physical activity and exercise are potent lifestyle interventions for the reduction of several psychosomatic risks, including cardiovascular disease, diabetes and mild-to-moderate depression. The current review describes the studies which have utilised a metabolomics/ metabolite profiling approach in combination with exercise in the period between 1999-2014 in predominantly healthy subjects (N:64) and in a smaller subset of patient cohorts (N:10) between 2011-2014. A broad range of intervention types were used in both healthy and patient cohorts with varying exercise regimes with or without supplement use. Effects on purine metabolism, which have been known for over 40 years, were by far the most well-cited and persistent finding. Other reported effects included observations of: glucocorticoid and androgen metabolism, glycolysis and Krebs cycle, gluconeogenesis, fatty acid metabolism, fatty acid oxidation and pantothenic acid, amino acid oxidation, tryptophan metabolism and effects on microbiome metabolites. The discussion section draws observations from the very disparate studies together and links them to the general aspects of human metabolism.",
keywords = "human, metabolomics, microbiome, physical activity, purine metabolism, training effect",
author = "Evangelia Daskalaki and Chris Easton and Watson, {David G.}",
year = "2014",
doi = "10.2174/2213235X03666150211000831",
language = "English",
volume = "2",
pages = "233--263",
journal = "Current Metabolomics",
issn = "2213-235X",
number = "4",

}

The application of metabolomic profiling to the effects of physical activity. / Daskalaki, Evangelia; Easton, Chris ; Watson, David G.

In: Current Metabolomics, Vol. 2, No. 4, 2014, p. 233-263.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The application of metabolomic profiling to the effects of physical activity

AU - Daskalaki, Evangelia

AU - Easton, Chris

AU - Watson, David G.

PY - 2014

Y1 - 2014

N2 - Physical activity and exercise are potent lifestyle interventions for the reduction of several psychosomatic risks, including cardiovascular disease, diabetes and mild-to-moderate depression. The current review describes the studies which have utilised a metabolomics/ metabolite profiling approach in combination with exercise in the period between 1999-2014 in predominantly healthy subjects (N:64) and in a smaller subset of patient cohorts (N:10) between 2011-2014. A broad range of intervention types were used in both healthy and patient cohorts with varying exercise regimes with or without supplement use. Effects on purine metabolism, which have been known for over 40 years, were by far the most well-cited and persistent finding. Other reported effects included observations of: glucocorticoid and androgen metabolism, glycolysis and Krebs cycle, gluconeogenesis, fatty acid metabolism, fatty acid oxidation and pantothenic acid, amino acid oxidation, tryptophan metabolism and effects on microbiome metabolites. The discussion section draws observations from the very disparate studies together and links them to the general aspects of human metabolism.

AB - Physical activity and exercise are potent lifestyle interventions for the reduction of several psychosomatic risks, including cardiovascular disease, diabetes and mild-to-moderate depression. The current review describes the studies which have utilised a metabolomics/ metabolite profiling approach in combination with exercise in the period between 1999-2014 in predominantly healthy subjects (N:64) and in a smaller subset of patient cohorts (N:10) between 2011-2014. A broad range of intervention types were used in both healthy and patient cohorts with varying exercise regimes with or without supplement use. Effects on purine metabolism, which have been known for over 40 years, were by far the most well-cited and persistent finding. Other reported effects included observations of: glucocorticoid and androgen metabolism, glycolysis and Krebs cycle, gluconeogenesis, fatty acid metabolism, fatty acid oxidation and pantothenic acid, amino acid oxidation, tryptophan metabolism and effects on microbiome metabolites. The discussion section draws observations from the very disparate studies together and links them to the general aspects of human metabolism.

KW - human

KW - metabolomics

KW - microbiome

KW - physical activity

KW - purine metabolism

KW - training effect

UR - http://www.eurekaselect.com/128371/article

U2 - 10.2174/2213235X03666150211000831

DO - 10.2174/2213235X03666150211000831

M3 - Article

VL - 2

SP - 233

EP - 263

JO - Current Metabolomics

T2 - Current Metabolomics

JF - Current Metabolomics

SN - 2213-235X

IS - 4

ER -