The aortic valve: structure, complications and implications for transcatheter aortic valve replacement

MM Rozeik, DJ Wheatley, T Gourlay

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Abstract

The aortic valve operates in a complex haemodynamic environment, opening and closing over 100,000 times a day. When complications arise, such as aortic stenosis, prognosis can be very poor, leading to death within the first few years. Surgical valve replacement is currently the standard treatment for aortic stenosis. A thorough understanding of the anatomy and function of the native valve is imperative when developing a prosthetic replacement that can withstand the complex demands of the heart. This review focuses on the anatomy, structure and disease of the aortic valve and the implications for a transcatheter aortic valve replacement (TAVR). Current complications with TAVR, such as major vascular bleeding, conduction disturbances and patient-prosthesis mismatch (PPM), can be overcome by reducing the delivery profile and through the use of more accurate imaging technologies to work towards a fully functional and durable prosthesis.

Original languageEnglish
Pages (from-to)285-300
Number of pages16
JournalPerfusion
Volume29
Issue number4
Early online date25 Feb 2014
DOIs
Publication statusPublished - Jul 2014

Keywords

  • aortic valve disease
  • valve structure
  • aortic valve replacement
  • transcatheter
  • heart valves

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