The actions of three diaminopyridines on the chick biventer cervicis muscle

Alan L. Harvey, Ian G. Marshall

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The effects of 2,3-, 2,6- and 3,4-diaminopyridine were investigated on the isolated chick biventer cervicis muscle preparation. All three compounds reversed tubocurarine blockade and augmented twitch height in indirectly stimulated preparations. Less twitch augmented was observed in directly stimulated preparations. 3,4-Diaminopyridine was the most effective of the compounds in facilitating neuromuscular transmission, but exhibited less convulsant activity than 4-aminopyridine. 3,4- and 2,3-diaminopyridine in high concentrations caused contractures that were inhibited by erabutoxin b or by β-bungarotoxin. It is suggested that the diaminopyridines increase both evoked and spontaneous acetylcholine release.

LanguageEnglish
Pages303-309
Number of pages7
JournalEuropean Journal of Pharmacology
Volume44
Issue number4
DOIs
Publication statusPublished - 15 Aug 1977

Fingerprint

Convulsants
Bungarotoxins
Tubocurarine
4-Aminopyridine
Contracture
Acetylcholine
Muscles
3,4-diaminopyridine
2,4-diaminopyridine
erabutoxin b
2,3-diaminopyridine

Keywords

  • acetylcholine release
  • chick biventer cervicis muscle
  • diaminopyridines
  • neuromuscular transmission
  • convulsion
  • diaminopyridine
  • dose response
  • drug antagonism
  • intraperitoneal drug administration
  • muscle fiber membrane potential

Cite this

@article{c22a02f7b0d54ed3a27458ce85f05176,
title = "The actions of three diaminopyridines on the chick biventer cervicis muscle",
abstract = "The effects of 2,3-, 2,6- and 3,4-diaminopyridine were investigated on the isolated chick biventer cervicis muscle preparation. All three compounds reversed tubocurarine blockade and augmented twitch height in indirectly stimulated preparations. Less twitch augmented was observed in directly stimulated preparations. 3,4-Diaminopyridine was the most effective of the compounds in facilitating neuromuscular transmission, but exhibited less convulsant activity than 4-aminopyridine. 3,4- and 2,3-diaminopyridine in high concentrations caused contractures that were inhibited by erabutoxin b or by β-bungarotoxin. It is suggested that the diaminopyridines increase both evoked and spontaneous acetylcholine release.",
keywords = "acetylcholine release, chick biventer cervicis muscle, diaminopyridines, neuromuscular transmission, convulsion, diaminopyridine, dose response, drug antagonism, intraperitoneal drug administration, muscle fiber membrane potential",
author = "Harvey, {Alan L.} and Marshall, {Ian G.}",
year = "1977",
month = "8",
day = "15",
doi = "10.1016/0014-2999(77)90303-X",
language = "English",
volume = "44",
pages = "303--309",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
number = "4",

}

The actions of three diaminopyridines on the chick biventer cervicis muscle. / Harvey, Alan L.; Marshall, Ian G.

In: European Journal of Pharmacology, Vol. 44, No. 4, 15.08.1977, p. 303-309.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The actions of three diaminopyridines on the chick biventer cervicis muscle

AU - Harvey, Alan L.

AU - Marshall, Ian G.

PY - 1977/8/15

Y1 - 1977/8/15

N2 - The effects of 2,3-, 2,6- and 3,4-diaminopyridine were investigated on the isolated chick biventer cervicis muscle preparation. All three compounds reversed tubocurarine blockade and augmented twitch height in indirectly stimulated preparations. Less twitch augmented was observed in directly stimulated preparations. 3,4-Diaminopyridine was the most effective of the compounds in facilitating neuromuscular transmission, but exhibited less convulsant activity than 4-aminopyridine. 3,4- and 2,3-diaminopyridine in high concentrations caused contractures that were inhibited by erabutoxin b or by β-bungarotoxin. It is suggested that the diaminopyridines increase both evoked and spontaneous acetylcholine release.

AB - The effects of 2,3-, 2,6- and 3,4-diaminopyridine were investigated on the isolated chick biventer cervicis muscle preparation. All three compounds reversed tubocurarine blockade and augmented twitch height in indirectly stimulated preparations. Less twitch augmented was observed in directly stimulated preparations. 3,4-Diaminopyridine was the most effective of the compounds in facilitating neuromuscular transmission, but exhibited less convulsant activity than 4-aminopyridine. 3,4- and 2,3-diaminopyridine in high concentrations caused contractures that were inhibited by erabutoxin b or by β-bungarotoxin. It is suggested that the diaminopyridines increase both evoked and spontaneous acetylcholine release.

KW - acetylcholine release

KW - chick biventer cervicis muscle

KW - diaminopyridines

KW - neuromuscular transmission

KW - convulsion

KW - diaminopyridine

KW - dose response

KW - drug antagonism

KW - intraperitoneal drug administration

KW - muscle fiber membrane potential

UR - http://www.scopus.com/inward/record.url?scp=0017656523&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(77)90303-X

DO - 10.1016/0014-2999(77)90303-X

M3 - Article

VL - 44

SP - 303

EP - 309

JO - European Journal of Pharmacology

T2 - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 4

ER -