The actions of three diaminopyridines on the chick biventer cervicis muscle

Alan L. Harvey, Ian G. Marshall

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The effects of 2,3-, 2,6- and 3,4-diaminopyridine were investigated on the isolated chick biventer cervicis muscle preparation. All three compounds reversed tubocurarine blockade and augmented twitch height in indirectly stimulated preparations. Less twitch augmented was observed in directly stimulated preparations. 3,4-Diaminopyridine was the most effective of the compounds in facilitating neuromuscular transmission, but exhibited less convulsant activity than 4-aminopyridine. 3,4- and 2,3-diaminopyridine in high concentrations caused contractures that were inhibited by erabutoxin b or by β-bungarotoxin. It is suggested that the diaminopyridines increase both evoked and spontaneous acetylcholine release.

Original languageEnglish
Pages (from-to)303-309
Number of pages7
JournalEuropean Journal of Pharmacology
Volume44
Issue number4
DOIs
Publication statusPublished - 15 Aug 1977

Keywords

  • acetylcholine release
  • chick biventer cervicis muscle
  • diaminopyridines
  • neuromuscular transmission
  • convulsion
  • diaminopyridine
  • dose response
  • drug antagonism
  • intraperitoneal drug administration
  • muscle fiber membrane potential

Cite this