The α-effect in iminium ion catalysis

Julie L. Cavill, Richard L. Elliott, Gareth Evans, Ian L. Jones, James A. Platts, Antonio M. Ruda, Nicholas C. O. Tomkinson

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The α-effect can be used as an effective means to promote iminium ion catalyzed transformations, providing acyclic scaffolds to aid in catalyst design. A thorough investigation of the structure-activity relationship of the catalyst architecture reveals optimal substituents of a disubstituted carbamate and a secondary alkyl group around a hydrazine scaffold. Mol. modeling investigations provide a mechanistic rationale to the results obsd.
Original languageUndefined/Unknown
Pages (from-to)410-421
Number of pages12
JournalTetrahedron
Volume62
Issue number2-3
DOIs
Publication statusPublished - 2005

Keywords

  • ion catalysis
  • iminium ion catalysis
  • hydrazine scaffold

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