Tetrazine‐responsive self‐immolative linkers

Kevin Neumann, Sarthak Jain, Alessia Gambardella, Sarah E. Walker, Elsa Valero, Annamaria Lilienkampf, Mark Bradley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.
LanguageEnglish
Pages91-95
Number of pages5
JournalChembiochem
Volume18
Issue number1
Early online date14 Nov 2016
DOIs
Publication statusPublished - 3 Jan 2017

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Doxorubicin
Chemical activation
Molecules
Water
Modulation

Keywords

  • Diels–Alder reaction
  • doxorubicin
  • nanoparticles
  • prodrugs
  • tetrazine

Cite this

Neumann, K., Jain, S., Gambardella, A., Walker, S. E., Valero, E., Lilienkampf, A., & Bradley, M. (2017). Tetrazine‐responsive self‐immolative linkers. Chembiochem, 18(1), 91-95. https://doi.org/10.1002/cbic.201600560
Neumann, Kevin ; Jain, Sarthak ; Gambardella, Alessia ; Walker, Sarah E. ; Valero, Elsa ; Lilienkampf, Annamaria ; Bradley, Mark. / Tetrazine‐responsive self‐immolative linkers. In: Chembiochem. 2017 ; Vol. 18, No. 1. pp. 91-95.
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Neumann, K, Jain, S, Gambardella, A, Walker, SE, Valero, E, Lilienkampf, A & Bradley, M 2017, 'Tetrazine‐responsive self‐immolative linkers' Chembiochem, vol. 18, no. 1, pp. 91-95. https://doi.org/10.1002/cbic.201600560

Tetrazine‐responsive self‐immolative linkers. / Neumann, Kevin; Jain, Sarthak; Gambardella, Alessia; Walker, Sarah E.; Valero, Elsa; Lilienkampf, Annamaria; Bradley, Mark.

In: Chembiochem, Vol. 18, No. 1, 03.01.2017, p. 91-95.

Research output: Contribution to journalArticle

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AU - Neumann, Kevin

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Neumann K, Jain S, Gambardella A, Walker SE, Valero E, Lilienkampf A et al. Tetrazine‐responsive self‐immolative linkers. Chembiochem. 2017 Jan 3;18(1):91-95. https://doi.org/10.1002/cbic.201600560