Tetrazine‐responsive self‐immolative linkers

Kevin Neumann, Sarthak Jain, Alessia Gambardella, Sarah E. Walker, Elsa Valero, Annamaria Lilienkampf, Mark Bradley

Research output: Contribution to journalArticle

27 Citations (Scopus)
68 Downloads (Pure)

Abstract

Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.
Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalChembiochem
Volume18
Issue number1
Early online date14 Nov 2016
DOIs
Publication statusPublished - 3 Jan 2017

Keywords

  • Diels–Alder reaction
  • doxorubicin
  • nanoparticles
  • prodrugs
  • tetrazine

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  • Cite this

    Neumann, K., Jain, S., Gambardella, A., Walker, S. E., Valero, E., Lilienkampf, A., & Bradley, M. (2017). Tetrazine‐responsive self‐immolative linkers. Chembiochem, 18(1), 91-95. https://doi.org/10.1002/cbic.201600560