Tetrazine‐responsive self‐immolative linkers

Kevin Neumann; Sarthak Jain; Alessia Gambardella; Sarah E. Walker; Elsa Valero; Annamaria Lilienkampf; Mark Bradley

doi:10.1002/cbic.201600560

Tetrazine‐responsive self‐immolative linkers

Kevin Neumann, Sarthak Jain, Alessia Gambardella, Sarah E. Walker, Elsa Valero, Annamaria Lilienkampf, Mark Bradley

Pure And Applied Chemistry

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41 Citations (Scopus)

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Abstract

Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

Original language	English
Pages (from-to)	91-95
Number of pages	5
Journal	Chembiochem
Volume	18
Issue number	1
Early online date	14 Nov 2016
DOIs	https://doi.org/10.1002/cbic.201600560
Publication status	Published - 3 Jan 2017

Keywords

Diels–Alder reaction
doxorubicin
nanoparticles
prodrugs
tetrazine

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Neumann-etal-Chembiochem-2016-Tetrazine‐responsive-self‐immolative-linkersAccepted author manuscript, 1.28 MB

Cite this

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AU - Neumann, Kevin

AU - Jain, Sarthak

AU - Gambardella, Alessia

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AU - Lilienkampf, Annamaria

AU - Bradley, Mark

PY - 2017/1/3

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N2 - Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

AB - Molecules that undergo activation or modulation following the addition of benign external small‐molecule chemical stimuli have numerous applications. Here, we report the highly efficient “decaging” of a variety of moieties by activation of a “self‐immolative” linker, by application of water‐soluble and stable tetrazine, including the controlled delivery of doxorubicin in a cellular context.

KW - Diels–Alder reaction

KW - doxorubicin

KW - nanoparticles

KW - prodrugs

KW - tetrazine

UR - https://research.ed.ac.uk/portal/en/publications/tetrazineresponsive-selfimmolative-linkers(c50de6e8-57b1-47a7-920a-62d29a47e0bc).html

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Tetrazine‐responsive self‐immolative linkers

Abstract

Keywords

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