Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil

Rosângela Maria Gomes, Augusto Afonso Guerra Júnior, Livia Lovato Pires de Lemos, Juliana de Oliveira Costa, Alessandra Maciel Almeida, Juliana Álvares, Charles Simão Filho, Mariangela Leal Cherchiglia, Eli Iola Gurgel Andrade, Brian Godman, Francisco de Assis Acúrcio

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.
LanguageEnglish
Pages991-999
Number of pages9
JournalExpert Review of Clinical Pharmacology
Volume9
Issue number7
Early online date16 Jun 2016
DOIs
Publication statusPublished - 1 Jul 2016

Fingerprint

Tacrolimus
Cyclosporine
Brazil
Transplants
Kidney
Graft Survival
Dialysis
Immunosuppressive Agents
Chronic Renal Insufficiency
Proportional Hazards Models
Kidney Transplantation
Survival Rate
Public Health
Medicine
Tissue Donors
Survival

Keywords

  • immunosuppressants
  • kidney transplant survival
  • chronic kidney disease
  • kidney function

Cite this

Gomes, R. M., Guerra Júnior, A. A., Lovato Pires de Lemos, L., de Oliveira Costa, J., Almeida, A. M., Álvares, J., ... de Assis Acúrcio, F. (2016). Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. Expert Review of Clinical Pharmacology, 9(7), 991-999. https://doi.org/10.1080/17512433.2016.1190270
Gomes, Rosângela Maria ; Guerra Júnior, Augusto Afonso ; Lovato Pires de Lemos, Livia ; de Oliveira Costa, Juliana ; Almeida, Alessandra Maciel ; Álvares, Juliana ; Simão Filho, Charles ; Cherchiglia, Mariangela Leal ; Gurgel Andrade, Eli Iola ; Godman, Brian ; de Assis Acúrcio, Francisco. / Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. In: Expert Review of Clinical Pharmacology. 2016 ; Vol. 9, No. 7. pp. 991-999.
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Gomes, RM, Guerra Júnior, AA, Lovato Pires de Lemos, L, de Oliveira Costa, J, Almeida, AM, Álvares, J, Simão Filho, C, Cherchiglia, ML, Gurgel Andrade, EI, Godman, B & de Assis Acúrcio, F 2016, 'Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil' Expert Review of Clinical Pharmacology, vol. 9, no. 7, pp. 991-999. https://doi.org/10.1080/17512433.2016.1190270

Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. / Gomes, Rosângela Maria; Guerra Júnior, Augusto Afonso; Lovato Pires de Lemos, Livia; de Oliveira Costa, Juliana; Almeida, Alessandra Maciel; Álvares, Juliana; Simão Filho, Charles; Cherchiglia, Mariangela Leal; Gurgel Andrade, Eli Iola; Godman, Brian; de Assis Acúrcio, Francisco.

In: Expert Review of Clinical Pharmacology, Vol. 9, No. 7, 01.07.2016, p. 991-999.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil

AU - Gomes, Rosângela Maria

AU - Guerra Júnior, Augusto Afonso

AU - Lovato Pires de Lemos, Livia

AU - de Oliveira Costa, Juliana

AU - Almeida, Alessandra Maciel

AU - Álvares, Juliana

AU - Simão Filho, Charles

AU - Cherchiglia, Mariangela Leal

AU - Gurgel Andrade, Eli Iola

AU - Godman, Brian

AU - de Assis Acúrcio, Francisco

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.

AB - Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.

KW - immunosuppressants

KW - kidney transplant survival

KW - chronic kidney disease

KW - kidney function

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U2 - 10.1080/17512433.2016.1190270

DO - 10.1080/17512433.2016.1190270

M3 - Article

VL - 9

SP - 991

EP - 999

JO - Expert Review of Clinical Pharmacology

T2 - Expert Review of Clinical Pharmacology

JF - Expert Review of Clinical Pharmacology

SN - 1751-2433

IS - 7

ER -

Gomes RM, Guerra Júnior AA, Lovato Pires de Lemos L, de Oliveira Costa J, Almeida AM, Álvares J et al. Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. Expert Review of Clinical Pharmacology. 2016 Jul 1;9(7):991-999. https://doi.org/10.1080/17512433.2016.1190270