Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil

Rosângela Maria Gomes, Augusto Afonso Guerra Júnior, Livia Lovato Pires de Lemos, Juliana de Oliveira Costa, Alessandra Maciel Almeida, Juliana Álvares, Charles Simão Filho, Mariangela Leal Cherchiglia, Eli Iola Gurgel Andrade, Brian Godman, Francisco de Assis Acúrcio

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Abstract

Background: Cyclosporine and tacrolimus are well established immunosuppressants; however little know about long term survival rates. Aim: Compare 10-year graft survival and associated factors among kidney transplant patients within the Brazilian Public Health system (SUS) prescribed either medicine. Methods: Analyze a national cohort of kidney transplant recipients within SUS. Graft loss defined by death or dialysis for more than three months. Kaplan-Meier method used to estimate cumulative probabilities of survival. Cox proportional hazards model used to evaluate factors associated with progression to graft loss. Results: 13,811 patients were included, 5,887 used cyclosporine and 7,924 tacrolimus. A higher risk of graft loss was associated with tacrolimus, a deceased donor, additional years of age, median period of dialysis greater than 47 months, diagnosis of diabetes as the primary cause of chronic kidney disease and transplantation between 2005 and 2009. Conclusions: Among other factors, tacrolimus-based regimens were associated with worse graft survival.
Original languageEnglish
Pages (from-to)991-999
Number of pages9
JournalExpert Review of Clinical Pharmacology
Volume9
Issue number7
Early online date16 Jun 2016
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • immunosuppressants
  • kidney transplant survival
  • chronic kidney disease
  • kidney function

Cite this

Gomes, R. M., Guerra Júnior, A. A., Lovato Pires de Lemos, L., de Oliveira Costa, J., Almeida, A. M., Álvares, J., Simão Filho, C., Cherchiglia, M. L., Gurgel Andrade, E. I., Godman, B., & de Assis Acúrcio, F. (2016). Ten-year kidney transplant survival of cyclosporine- or tacrolimus-treated patients in Brazil. Expert Review of Clinical Pharmacology, 9(7), 991-999. https://doi.org/10.1080/17512433.2016.1190270