Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 925-934 |
| Number of pages | 10 |
| Journal | Ultrasound in Medicine and Biology |
| Volume | 36 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 30 Jun 2010 |
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Keywords
- ultrasound
- contrast agents
- microbubbles
- temperature
- attenuation
- scattering
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Temperature dependent behavior of ultrasound contrast agents. / Mulvana, Helen; Stride, Eleanor; Hajnal, Jo V.; Eckersley, Robert J.
In: Ultrasound in Medicine and Biology, Vol. 36, No. 6, 30.06.2010, p. 925-934.Research output: Contribution to journal › Article
TY - JOUR
T1 - Temperature dependent behavior of ultrasound contrast agents
AU - Mulvana, Helen
AU - Stride, Eleanor
AU - Hajnal, Jo V.
AU - Eckersley, Robert J.
PY - 2010/6/30
Y1 - 2010/6/30
N2 - Recent interest in ultrasound contrast agents (UCAs) as tools for quantitative imaging and therapy has increased the need for accurate characterization. Laboratory investigations are frequently undertaken in a water bath at room temperature; however, implications for in vivo applications are not presented. Acoustic investigation of a bulk suspension of SonoVue (Bracco Research, Geneva, Switzerland) was made in a water bath at temperatures of 20–45 °C. UCA characteristics were significantly affected by temperature, particularly between 20 and 40 °C, leading to an increase in attenuation from 1.7–2.5 dB, respectively (p = 0.002) and a 2-dB increase in scattered signal over the same range (p = 0.05) at an insonation pressure of 100 kPa. Optical data supported the hypothesis that a temperature-mediated increase in diameter was the dominant cause, and revealed a decrease in bubble stability. In conclusion, measurements made at room temperature require careful interpretation with regard to behavior in vivo.
AB - Recent interest in ultrasound contrast agents (UCAs) as tools for quantitative imaging and therapy has increased the need for accurate characterization. Laboratory investigations are frequently undertaken in a water bath at room temperature; however, implications for in vivo applications are not presented. Acoustic investigation of a bulk suspension of SonoVue (Bracco Research, Geneva, Switzerland) was made in a water bath at temperatures of 20–45 °C. UCA characteristics were significantly affected by temperature, particularly between 20 and 40 °C, leading to an increase in attenuation from 1.7–2.5 dB, respectively (p = 0.002) and a 2-dB increase in scattered signal over the same range (p = 0.05) at an insonation pressure of 100 kPa. Optical data supported the hypothesis that a temperature-mediated increase in diameter was the dominant cause, and revealed a decrease in bubble stability. In conclusion, measurements made at room temperature require careful interpretation with regard to behavior in vivo.
KW - ultrasound
KW - contrast agents
KW - microbubbles
KW - temperature
KW - attenuation
KW - scattering
U2 - 10.1016/j.ultrasmedbio.2010.03.003
DO - 10.1016/j.ultrasmedbio.2010.03.003
M3 - Article
VL - 36
SP - 925
EP - 934
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 6
ER -