Recent interest in ultrasound contrast agents (UCAs) as tools for quantitative imaging and therapy has increased the need for accurate characterization. Laboratory investigations are frequently undertaken in a water bath at room temperature; however, implications for in vivo applications are not presented. Acoustic investigation of a bulk suspension of SonoVue (Bracco Research, Geneva, Switzerland) was made in a water bath at temperatures of 20–45 °C. UCA characteristics were significantly affected by temperature, particularly between 20 and 40 °C, leading to an increase in attenuation from 1.7–2.5 dB, respectively (p = 0.002) and a 2-dB increase in scattered signal over the same range (p = 0.05) at an insonation pressure of 100 kPa. Optical data supported the hypothesis that a temperature-mediated increase in diameter was the dominant cause, and revealed a decrease in bubble stability. In conclusion, measurements made at room temperature require careful interpretation with regard to behavior in vivo.
|Number of pages||10|
|Journal||Ultrasound in Medicine and Biology|
|Publication status||Published - 30 Jun 2010|
- contrast agents
Mulvana, H., Stride, E., Hajnal, J. V., & Eckersley, R. J. (2010). Temperature dependent behavior of ultrasound contrast agents. Ultrasound in Medicine and Biology, 36(6), 925-934. https://doi.org/10.1016/j.ultrasmedbio.2010.03.003