Targeted cancer phototherapy using phthalocyanine–anticancer drug conjugates

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Abstract

Phototherapy, the use of light to selectively ablate cancerous tissue, is a compelling prospect. Phototherapy is divided into two major domains: photodynamic and photothermal, whereby photosensitizer irradiation generates reactive oxygen species or heat, respectively, to disrupt the cancer microenvironment. Phthalocyanines (Pcs) are prominent phototherapeutics due to their desirable optical properties and structural versatility. Targeting of Pc photosensitizers historically relied on the enhanced permeation and retention effect, but the weak specificity engendered by this approach has hindered bench-to-clinic translation. To improve specificity, antibody and peptide active-targeting groups have been employed to some effect. An alternative targeting method exploits the binding of anticancer drugs to direct the photosensitizer close to essential cellular components, allowing for precise, synergistic phototherapy. This Perspective explores the use of Pc–drug conjugates as targeted anticancer phototherapeutic systems with examples of Pc–platin, Pc–kinase, and Pc–anthracycline conjugates discussed in detail.
Original languageEnglish
Pages (from-to)13157-13175
Number of pages19
JournalDalton Transactions
Volume51
Issue number35
Early online date17 Aug 2022
DOIs
Publication statusE-pub ahead of print - 17 Aug 2022

Keywords

  • phthalocyanine
  • photodynamic therapy
  • photosensitizer
  • anti-cancer
  • drug conjugate

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