Tandem chemoselective Suzuki-Miyaura cross-coupling enabled by nucleophile speciation control

Ciaran P. Seath, James W. B. Fyfe, John J. Molloy, Allan J. B. Watson

Research output: Contribution to journalArticle

43 Citations (Scopus)
130 Downloads (Pure)

Abstract

Control of boronic acid speciation is presented as a strategy to achieve nucleophile chemoselectivity in the Suzuki-Miyaura reaction. Combined with simultaneous control of oxidative addition and transmetallation, this enables chemoselective formation of two C-C bonds in a single operation, providing a method for the rapid preparation of highly functionalized carbogenic frameworks.
Original languageEnglish
Pages (from-to)9976-9979
Number of pages4
JournalAngewandte Chemie
Volume54
Issue number34
Early online date1 Jul 2015
DOIs
Publication statusPublished - 17 Aug 2015

Keywords

  • boron
  • chemoselectivity
  • cross-coupling
  • palladium
  • speciation

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