Tandem chemoselective Suzuki-Miyaura cross-coupling enabled by nucleophile speciation control

Ciaran P. Seath, James W. B. Fyfe, John J. Molloy, Allan J. B. Watson

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Control of boronic acid speciation is presented as a strategy to achieve nucleophile chemoselectivity in the Suzuki-Miyaura reaction. Combined with simultaneous control of oxidative addition and transmetallation, this enables chemoselective formation of two C-C bonds in a single operation, providing a method for the rapid preparation of highly functionalized carbogenic frameworks.
LanguageEnglish
Pages9976-9979
Number of pages4
JournalAngewandte Chemie
Volume54
Issue number34
Early online date1 Jul 2015
DOIs
Publication statusPublished - 17 Aug 2015

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Boronic Acids
Nucleophiles

Keywords

  • boron
  • chemoselectivity
  • cross-coupling
  • palladium
  • speciation

Cite this

Seath, Ciaran P. ; Fyfe, James W. B. ; Molloy, John J. ; Watson, Allan J. B. / Tandem chemoselective Suzuki-Miyaura cross-coupling enabled by nucleophile speciation control. In: Angewandte Chemie. 2015 ; Vol. 54, No. 34. pp. 9976-9979.
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Tandem chemoselective Suzuki-Miyaura cross-coupling enabled by nucleophile speciation control. / Seath, Ciaran P.; Fyfe, James W. B.; Molloy, John J.; Watson, Allan J. B.

In: Angewandte Chemie, Vol. 54, No. 34, 17.08.2015, p. 9976-9979.

Research output: Contribution to journalArticle

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